Thanh D. Nguyen Laboratory

Associated Lab Members

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Thanh D. NguyenPh.D.
  • Associate Professor of Physics Research in Radiology

Thanh D. Nguyen, Ph.D., is an associate professor of physics in radiology with the Weill Cornell Medicine Magnetic Resonance Imaging Research Institute.

Ha Manh LuuPh.D.
  • Research Associate in Radiology

Lab Focus 

Dr. Nguyen’s scientific interests are centered on the development of quantitative magnetic resonance imaging (MRI) methods for the study of tissue properties. He has a background in electrical engineering with a focus on digital image processing. He has acquired expertise in MR physics and pulse sequence programming. He has significant experience in developing and translating advanced MRI pulse sequences for cardiovascular and neurological applications, including free-breathing coronary artery MR angiography and myocardial viability imaging, black-blood vessel wall imaging, myocardial T1 mapping, myelin water fraction mapping, carotid plaque characterization for stroke risk prediction, tissue iron and oxygenation quantification using quantitative susceptibility mapping (QSM), and tissue perfusion imaging. He has a productive record of leading and participating in research projects funded by the National Institutes of Health (NIH) and the National Multiple Sclerosis Society. 

Research Areas  

Multiple sclerosis (MS), carotid plaque and stroke, heart, the blood-brain-barrier and glymphatic system, neurodegenerative diseases


Quantitative susceptibility mapping (QSM), myelin water imaging, relaxometry, pulse sequence programming, image reconstruction, motion correction


Ajay Gupta, M.D.
Jana Ivanidze, M.D., Ph.D.
Hooman Kamel, M.D. 
Yi Li, Ph.D.
Jarek Wegiel, Ph.D.

Recent Publications

  1. Zinger N., et al., Dimethyl Fumarate Reduces Inflammation in Chronic Active Multiple Sclerosis Lesions, Neurol. Neuroimmunol. Neuroinflamm.: 2022 Mar;9(2).

  2. Cho J., et al., Brain oxygen extraction fraction mapping in patients with multiple sclerosis, J. Cereb. Blood Flow Metab.: 2022 Feb;42(2):338-348.  

  3. Li J., et al., Cerebral Microbleeds Are Associated With Increased Brain Iron and Cognitive Impairment in Patients With Cerebral Small Vessel Disease: A Quantitative Susceptibility Mapping Study, J. Magn. Reson. Imaging.: 2022 Jan 31.

  4. Kim J., et al., Subsecond accurate myelin water fraction reconstruction from FAST-T2 data with 3D UNET, Magn Reson Med.: 2022 Jan 28.

  5. Cho J., et al., Temporal clustering, tissue composition, and total variation for mapping oxygen extraction fraction using QSM and quantitative BOLD, Magn. Reson. Med.: 2021 Nov;86 (5):2635-2646. 

  6. Wen Y., et al., Multiecho complex total field inversion method (mcTFI) for improved signal modeling in quantitative susceptibility mapping, Magn. Reson. Med.: 2021 Oct;86(4):2165-2178.  

  7. Zhou L., et al., Quantitative transport mapping (QTM) of the kidney with an approximate microvascular network, Magn. Reson. Med.: 2021 Apr;85(4):2247-2262. 

  8. Sweeney E.M., et al., Estimation of Multiple Sclerosis lesion age on magnetic resonance imaging, Neuroimage.: 2021 Jan 15;225:117451. 

  9. Nguyen T.D., et al., Quantitative susceptibility mapping of carotid plaques using nonlinear total field inversion: Initial experience in patients with significant carotid stenosis, Magn. Reson. Med.: 2020 Sep;84(3):1501-1509. 

  10. Zhang J., et al., Fidelity imposed network edit (FINE) for solving ill-posed image reconstruction, Neuroimage.: 2020 May 1;211:116579. 

Research Projects

Award or Grant: R01 AG079326-01

The team’s objective is to develop a new imaging method for quantitative mapping of parenchymal cerebrospinal fluid fraction (CSFF). The team’s preliminary data showed CSFF increased in Alzheimer’s disease (AD) and was associated with...

Award or Grant: R01 AG077594-01 (not yet funded)

The team’s objective is to develop quantitative permeability mapping (QPM) of kW, the water exchange rate...

Award or Grant: R21 NS116516; R01 NS123576-01A1 (not yet funded)

The team’s key objective is to use quantitative susceptibility mapping (QSM) to establish reliable, noninvasive magnetic resonance...

Award or Grant: National MS Society RR-1602-07671

The Nguyen Lab’s objective is to establish the association between lesion iron and subsequent myelin recovery in multiple sclerosis (MS)...

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065