Associated Lab Members
Jonathan Dyke, Ph.D., earned his doctorate in engineering from the University of Tennessee. He served as a Postdoctoral Fellow in Medical Physics at Memorial Sloan Kettering Cancer Center. A Professor of Physics Research in Radiology, he's been at WCM since 2001.
Dr. Dyke has been with the Citigroup Biomedical Imaging Center (CBIC) since its founding in 2002. The CBIC is a Weill Cornell Medicine (WCM) core facility that houses advanced imaging hardware supporting research in magnetic resonance imaging (MRI), positron emission tomography (PET), and other modalities from pre-clinical to clinical trials. He has significant research expertise in advanced MRI and magnetic resonance spectroscopy (MRS) techniques in oncology, orthopedics and neurodegenerative diseases. He supervises the daily operation of two 3.0 tesla (T) clinical MRI scanners, and a 7.0 T pre-clinical MRI scanner. He directs the computer infrastructure at the center, and maintains storage and distribution of imaging data. (All policies are in full accord with patient privacy and Health Insurance Portability and Accountability Act (HIPAA) regulations.) He also initiated a core animal imaging protocol with the Institutional Animal Care and Use Committee (IACUC) to facilitate pre-clinical imaging studies at the center.
We are pioneering the use of a novel phase-resolved functional lung (PREFUL) MRI protocol that does not require sedation, contrast administration, or radiation to measure ventilation, perfusion defects, and pulmonary perfusion in this vulnerable infant population. This information on lung function cannot be achieved by any other means....
Dr. Dyke’s Ph.D. work focused on compartmental modeling of a novel tumor- specific PET tracer used for dose planning of radiation therapy. He implemented novel pharmacokinetic compartmental model fitting of metabolic uptake of this...
Bone blood flow (BBF) and turnover may be altered in many disease states such as osteoarthritis (OA), bone marrow lesions, and trauma or fracture. Dr. Dyke’s group pioneered the use of pharmacokinetic magnetic resonance imaging (MRI) and positron emission...
Award or Grant: National Institutes of Health (NIH) (R01NS061848, U54NS065768). The Lysosomal Disease Network (U54NS065768), which is part of the National Center for Advancing Translational Sciences (...
As a post-doctoral fellow, Dr. Dyke developed the first technique at Memorial Sloan Kettering Cancer Center (MSKCC) to non-invasively assess the grade of neoadjuvant chemotherapy in pediatric subjects with osteogenic or Ewing’s sarcomas using dynamic...
Delivery of various drugs in both intrathecal and intracisternal spaces are being used to treat a myriad of diseases. Knowledge of the rate of drug delivery to each region in the brain via the CSF space may be estimated by using MRI. Our lab...
