Biomedical Ultrasound Research Laboratory (BURL)

BURL Directors

Jeff Ketterling

Jeff Ketterling, Ph.D., professor of biomedical engineering in radiology, received his B.S. in electrical engineering from the University of Washington in 1994, and his Ph.D. in mechanical engineering from Yale University in 1999. Jeff’s research focuses on the development and translation of ultrasound technology to basic science, and small-animal and clinical applications, particularly in the realm of high-frequency ultrasound. Recent projects include high-speed plane-wave ultrasound imaging for intracardiac flow patterns in mouse adult mice, blood flow in the front and back of the human eye, and activation of acoustic nanodrops for imaging microcirculation.

Jonathan Mamou

Jonathan Mamou, Ph.D., associate professor of electrical engineering in radiology, earned a B.S. in electrical engineering from the Ecole Nationale Superieure des Telecommunications in Paris, France, in 2000. He earned a Ph.D. in electrical engineering in 2005 from the University of Illinois at Urbana-Champaign. His fields of interest include theoretical aspects of ultrasonic scattering, ultrasonic medical imaging, ultrasound contrast agents, and biomedical image processing. Recent projects focus on quantitative ultrasound methods for ultrasound tissue characterization in oncology and ophthalmology, and ultra-high frequencies (>250 MHz) for quantitative acoustic microscopy, among others..

BURL Mission

The Biomedical Ultrasound Research Laboratory (BURL) of the Weil Cornell Medicine (WCM) Department of Radiology was formed in 2022. BURL is focused on using ultrasound for medical imaging and therapy. Projects and expertise span from technology development to clinical implementation.

BURL Scientific Objectives

The BURL conducts advanced research on a wide range of medical ultrasound topics including: therapeutic ultrasound, ultrasonic tissue characterization, ophthalmic imaging, high-frequency transducers, acoustic microscopy, signal- and image-processing, blood-flow imaging, and elastography. The goal of the BURL is to work closely with collaborators at WCM and around the world to develop methods and technologies that will directly address clinically relevant medical problems. 

BURL Core Activities

The BURL undertakes research and collaborations in a wide range of imaging and therapeutic research areas. Some recent focus areas include:  

  1. Tissue characterization using quantitative ultrasound methods on numerous organs (e.g., lymph nodes, thyroid, prostate, etc.) 
  2. Applying advanced Doppler methods to characterize blood-flow patterns in mouse models of cardiac disease.
  3. Evaluation of acoustic microstructure of tissue using acoustic microscopy with frequency >250 MHz  
  4. Study of vitreous echodensity as it relates to age-normal and myopic patient populations. 

BURL Laboratories

The BURL consists of researchers with advanced engineering degrees who work closely together with doctors and scientists at WCM on a wide variety of projects. The BURL maintains a well-equipped research facility with standard test-and-measurement equipment, acoustic- measurement equipment, optics components, prototype ultrasound instruments, advanced clinical ultrasound research machines, and computational hardware. 

Core BURL Laboratories

BURL Collaborators