Pharmacokinetic PET modeling of 18F-BPA-fructose in glioblastoma multiforme in BNCT

Completed Research Project
Jonathan Dyke, Ph.D., DABMP
Related Institute: 
Last Updated: 
October 25, 2023

Dr. Dyke’s Ph.D. work focused on compartmental modeling of a novel tumor- specific PET tracer used for dose planning of radiation therapy.  He implemented novel pharmacokinetic compartmental model fitting of metabolic uptake of this tracer in subjects presenting with glioblastoma multiforme brain tumors prior to therapy.  Uptake results were used to produce dose treatment plans prior to a novel radiation therapy (Boron Neuron Capture Therapy).   

Related Publications: Kabalka G.W., et al., Preliminary Evaluation of Fluorine-18-BPA-fructose for Boron Neutron Capture Treatment Planning,  J Nuc Med.: 1997;38:1762-1767. 

Associated Institution: University of Tennessee  

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065