Phase-Resolved Functional Lung (PREFUL) MRI of Ventilation and Perfusion in Premature Infants

We are pioneering the use of a novel phase-resolved functional lung (PREFUL) MRI protocol that does not require sedation, contrast administration, or radiation to measure ventilation, perfusion defects, and pulmonary perfusion in this vulnerable infant population. This information on lung function cannot be achieved by any other means. Our work at the new Alexandra Cohen Hospital for Women and Newborns will provide information on the root causes of bronchopulmonary dysplasia (BPD). It will assign a novel patient-specific severity score (ALP) to each infant that has never been done. 

This work (R01HL167003) is funded by the National Heart, Lung, and Blood Institute with co-PI, Dr. Arzu Kovanlikaya.