Our overall goal is to develop a fluid mechanics approach to studying tracer transport through tissue for perfusion quantification in magnetic resonance imaging (MRI), which is termed as quantitative transport mapping (QTM). Current/traditional perfusion quantification in MRI and medical imaging in general is based on Kety's method that assumes the same arterial input globally into all voxels in...
Dr. Dyke’s Ph.D. work focused on compartmental modeling of a novel tumor- specific PET tracer used for dose planning of radiation therapy. He implemented novel pharmacokinetic compartmental model fitting of metabolic uptake of this tracer in subjects presenting with glioblastoma multiforme brain tumors prior to therapy. Uptake results were used to produce dose treatment plans prior to a novel...
We are pioneering the use of a novel phase-resolved functional lung (PREFUL) MRI protocol that does not require sedation, contrast administration, or radiation to measure ventilation, perfusion defects, and pulmonary perfusion in this vulnerable infant population. This information on lung function cannot be achieved by any other means. Our work at the new Alexandra Cohen Hospital for Women and...
