Rapid dynamic contrast-enhanced MRI for small animals at 7T using 3D ultra-short echo time and golden-angle radial sparse parallel MRI.

TitleRapid dynamic contrast-enhanced MRI for small animals at 7T using 3D ultra-short echo time and golden-angle radial sparse parallel MRI.
Publication TypeJournal Article
Year of Publication2019
AuthorsZhang J, Feng L, Otazo R, Kim SGene
JournalMagn Reson Med
Volume81
Issue1
Pagination140-152
Date Published2019 01
ISSN1522-2594
KeywordsAlgorithms, Animals, Brain Neoplasms, Cell Line, Tumor, Contrast Media, Data Compression, Feasibility Studies, Image Enhancement, Image Interpretation, Computer-Assisted, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Kinetics, Magnetic Resonance Imaging, Mice, Mice, Inbred C57BL, Microcirculation, Neoplasm Transplantation, Spatiotemporal Analysis
Abstract

PURPOSE: To develop a rapid dynamic contrast-enhanced MRI method with high spatial and temporal resolution for small-animal imaging at 7 Tesla.

METHODS: An ultra-short echo time (UTE) pulse sequence using a 3D golden-angle radial sampling was implemented to achieve isotropic spatial resolution with flexible temporal resolution. Continuously acquired radial spokes were grouped into subsets for image reconstruction using a multicoil compressed sensing approach (Golden-angle RAdial Sparse Parallel; GRASP). The proposed 3D-UTE-GRASP method with high temporal and spatial resolutions was tested using 7 mice with GL261 intracranial glioma models.

RESULTS: Iterative reconstruction with different temporal resolutions and regularization factors λ showed that, in all cases, the cost function decreased to less than 2.5% of its starting value within 20 iterations. The difference between the time-intensity curves of 3D-UTE-GRASP and nonuniform fast Fourier transform (NUFFT) images was minimal when λ was 1% of the maximum signal intensity of the initial NUFFT images. The 3D isotropic images were used to generate pharmacokinetic parameter maps to show the detailed images of the tumor characteristics in 3D and also to show longitudinal changes during tumor growth.

CONCLUSION: This feasibility study demonstrated that the proposed 3D-UTE-GRASP method can be used for effective measurement of the 3D spatial heterogeneity of tumor pharmacokinetic parameters.

DOI10.1002/mrm.27357
Alternate JournalMagn Reson Med
PubMed ID30058079
PubMed Central IDPMC6258350
Grant ListP30 CA016087 / CA / NCI NIH HHS / United States
R01CA160620 / NH / NIH HHS / United States
5P30CA016087 / NH / NIH HHS / United States
P30 CA008748 / CA / NCI NIH HHS / United States
P41EB017183 / NH / NIH HHS / United States
R01 CA160620 / CA / NCI NIH HHS / United States
P41 EB017183 / EB / NIBIB NIH HHS / United States
Related Institute: 
MRI Research Institute (MRIRI)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065