| Title | Diffusion weighted imaging in predicting progression free survival in patients with squamous cell carcinomas of the head and neck treated with induction chemotherapy. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Berrak S, Chawla S, Kim S, Quon H, Sherman E, Loevner LA, Poptani H |
| Journal | Acad Radiol |
| Volume | 18 |
| Issue | 10 |
| Pagination | 1225-32 |
| Date Published | 2011 Oct |
| ISSN | 1878-4046 |
| Keywords | Aged, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Squamous Cell, Contrast Media, Diffusion Magnetic Resonance Imaging, Disease Progression, Female, Gadolinium DTPA, Head and Neck Neoplasms, Humans, Image Interpretation, Computer-Assisted, Lymphatic Metastasis, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Statistics, Nonparametric, Survival Analysis, Treatment Outcome |
| Abstract | RATIONALE AND OBJECTIVES: The aim of this study was to assess the role of diffusion-weighted imaging in predicting progression-free survival in patients with head and neck squamous cell carcinoma (HNSCC) treated with induction chemotherapy. MATERIALS AND METHODS: Eighteen patients with HNSCC underwent diffusion-weighted imaging studies prior to treatment and within 3 weeks after completion of induction chemotherapy. Median apparent diffusion coefficient (ADC) values were computed from the largest cervical metastatic lymph node. Percentage changes in ADC values from pretreatment to posttreatment time points were compared between alive and dead patients using the Mann-Whitney U test. P values < .05 were considered statistically significant. RESULTS: A 22% increase in ADC was observed after induction chemotherapy in alive patients (n = 15), while patients who died from HNSCC (n = 3) demonstrated a 33% decrease in ADC. The difference in percentage change in ADC between alive and dead patients was significant (P = .039). CONCLUSIONS: ADC may be a useful marker in predicting progression-free survival in patients with HNSCC undergoing induction chemotherapy. |
| DOI | 10.1016/j.acra.2011.06.009 |
| Alternate Journal | Acad Radiol |
| PubMed ID | 21835649 |
| PubMed Central ID | PMC3168957 |
| Grant List | R01 CA102756 / CA / NCI NIH HHS / United States R01 CA102756-04 / CA / NCI NIH HHS / United States R01-CA102756 / CA / NCI NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)