Title | Unambiguous identification of superparamagnetic iron oxide particles through quantitative susceptibility mapping of the nonlinear response to magnetic fields. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Liu T, Spincemaille P, de Rochefort L, Wong R, Prince M, Wang Y |
Journal | Magn Reson Imaging |
Volume | 28 |
Issue | 9 |
Pagination | 1383-9 |
Date Published | 2010 Nov |
ISSN | 1873-5894 |
Keywords | Air, Animals, Computer Simulation, Contrast Media, Ferric Compounds, Magnetics, Mice, Models, Theoretical, Phantoms, Imaging, Water |
Abstract | Superparamagnetic iron oxide (SPIO) particles generate signal void regions on gradient echo images due to their strong magnetization. In practice, the signal void region might be indistinguishable from that generated by air. However, the response of SPIO to an externally applied magnetic field is nonlinear. Magnetization of SPIO saturates at around 1 T while magnetization of water and air increase linearly with field strength. Phantom experiment and mice experiments demonstrated the feasibility of a nonambiguous identification of superparamagnetic contrast agents. |
DOI | 10.1016/j.mri.2010.06.011 |
Alternate Journal | Magn Reson Imaging |
PubMed ID | 20688448 |
PubMed Central ID | PMC2963706 |
Grant List | R01 HL060879 / HL / NHLBI NIH HHS / United States T35 EB006732 / EB / NIBIB NIH HHS / United States UL1 RR024996 / RR / NCRR NIH HHS / United States UL1RR024996 / RR / NCRR NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)