Test-retest repeatability of ADC in prostate using the multi b-Value VERDICT acquisition.

TitleTest-retest repeatability of ADC in prostate using the multi b-Value VERDICT acquisition.
Publication TypeJournal Article
Year of Publication2023
AuthorsRogers HJ, Singh S, Barnes A, Obuchowski NA, Margolis DJ, Malyarenko DI, Chenevert TL, Shukla-Dave A, Boss MA, Punwani S
JournalEur J Radiol
Volume162
Pagination110782
Date Published2023 May
ISSN1872-7727
KeywordsAged, Diffusion Magnetic Resonance Imaging, Humans, Male, Prospective Studies, Prostate, Prostatic Neoplasms, Retrospective Studies
Abstract

PURPOSE: VERDICT (Vascular, Extracellular, Restricted Diffusion for Cytometry in Tumours) MRI is a multi b-value, variable diffusion time DWI sequence that allows generation of ADC maps from different b-value and diffusion time combinations. The aim was to assess precision of prostate ADC measurements from varying b-value combinations using VERDICT and determine which protocol provides the most repeatable ADC.

MATERIALS AND METHODS: Forty-one men (median age: 67.7 years) from a prior prospective VERDICT study (April 2016-October 2017) were analysed retrospectively. Men who were suspected of prostate cancer and scanned twice using VERDICT were included. ADC maps were formed using 5b-value combinations and the within-subject standard deviations (wSD) were calculated per ADC map. Three anatomical locations were analysed per subject: normal TZ (transition zone), normal PZ (peripheral zone), and index lesions. Repeated measures ANOVAs showed which b-value range had the lowest wSD, Spearman correlation and generalized linear model regression analysis determined whether wSD was related to ADC magnitude and ROI size.

RESULTS: The mean lesion ADC for b0b1500 had the lowest wSD in most zones (0.18-0.58x10-4 mm2/s). The wSD was unaffected by ADC magnitude (Lesion: p = 0.064, TZ: p = 0.368, PZ: p = 0.072) and lesion Likert score (p = 0.95). wSD showed a decrease with ROI size pooled over zones (p = 0.019, adjusted regression coefficient = -1.6x10-3, larger ROIs for TZ versus PZ versus lesions). ADC maps formed with a maximum b-value of 500 s/mm2 had the largest wSDs (1.90-10.24x10-4 mm2/s).

CONCLUSION: ADC maps generated from b0b1500 have better repeatability in normal TZ, normal PZ, and index lesions.

DOI10.1016/j.ejrad.2023.110782
Alternate JournalEur J Radiol
PubMed ID37004362
PubMed Central IDPMC10334409
Grant ListR01 CA190299 / CA / NCI NIH HHS / United States
HHSN268201500021C / HL / NHLBI NIH HHS / United States
P30 CA008748 / CA / NCI NIH HHS / United States
HHSN268201300071C / EB / NIBIB NIH HHS / United States
75N91021C00036 / CA / NCI NIH HHS / United States
U01 CA211205 / CA / NCI NIH HHS / United States

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065