Title | Reduced retention of Pittsburgh compound B in white matter lesions. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Glodzik L, Rusinek H, Li J, Zhou C, Tsui W, Mosconi L, Li Y, Osorio R, Williams S, Randall C, Spector N, McHugh P, Murray J, Pirraglia E, Vallabhajolusa S, de Leon M |
Journal | Eur J Nucl Med Mol Imaging |
Volume | 42 |
Issue | 1 |
Pagination | 97-102 |
Date Published | 2015 Jan |
ISSN | 1619-7089 |
Keywords | Aged, Aniline Compounds, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Plaque, Amyloid, Positron-Emission Tomography, Radiopharmaceuticals, Thiazoles, White Matter |
Abstract | PURPOSE: One of the interesting features of the amyloid tracer Pittsburgh compound B (PiB) is that it generates a signal in the white matter (WM) in both healthy subjects and cognitively impaired individuals. This characteristic gave rise to the possibility that PiB could be used to trace WM pathology. In a group of cognitively healthy elderly we examined PiB retention in normal-appearing WM (NAWM) and WM lesions (WML), one of the most common brain pathologies in aging. METHODS: We segmented WML and NAWM on fluid attenuation inversion recovery (FLAIR) images of 73 subjects (age 61.9 ± 10.0, 71 % women). PiB PET images were corrected for partial volume effects and coregistered to FLAIR images and WM masks. WML and NAWM PiB signals were then extracted. RESULTS: PiB retention in WML was lower than in NAWM (p < 0.001, 14.6 % reduction). This was true both for periventricular WML (p < 0.001, 17.8 % reduction) and deep WML (p = 0.001, 7.5 % reduction). CONCLUSION: PiB binding in WM is influenced by the presence of WML, which lower the signal. Our findings add to the growing evidence that PiB can depict WM pathology and should prompt further investigations into PiB binding targets in WM. |
DOI | 10.1007/s00259-014-2897-1 |
Alternate Journal | Eur J Nucl Med Mol Imaging |
PubMed ID | 25331458 |
PubMed Central ID | PMC4415610 |
Grant List | 2R01AG013616-22 / AG / NIA NIH HHS / United States R01 HL111724 / HL / NHLBI NIH HHS / United States R01 AG035137 / AG / NIA NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States RC2 AG036502 / AG / NIA NIH HHS / United States HL111724-01 / HL / NHLBI NIH HHS / United States RC2-AG036502 / AG / NIA NIH HHS / United States R01-AG035137 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)