Title | Periodontal disease associates with higher brain amyloid load in normal elderly. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Kamer AR, Pirraglia E, Tsui W, Rusinek H, Vallabhajosula S, Mosconi L, Yi L, McHugh P, Craig RG, Svetcov S, Linker R, Shi C, Glodzik L, Williams S, Corby P, Saxena D, de Leon MJ |
Journal | Neurobiol Aging |
Volume | 36 |
Issue | 2 |
Pagination | 627-33 |
Date Published | 2015 Feb |
ISSN | 1558-1497 |
Keywords | Aged, Alzheimer Disease, Amyloid beta-Peptides, Aniline Compounds, Animals, Brain, Carbon Radioisotopes, Female, Humans, Male, Middle Aged, Periodontal Diseases, Phenanthrolines, Positron-Emission Tomography, Radiopharmaceuticals, Regression Analysis, Thiazoles |
Abstract | The accumulation of amyloid-β (Aβ) plaques is a central feature of Alzheimer's disease (AD). First reported in animal models, it remains uncertain if peripheral inflammatory and/or infectious conditions in humans can promote Aβ brain accumulation. Periodontal disease, a common chronic infection, has been previously reported to be associated with AD. Thirty-eight cognitively normal, healthy, and community-residing elderly (mean age, 61 and 68% female) were examined in an Alzheimer's Disease Research Center and a University-Based Dental School. Linear regression models (adjusted for age, apolipoprotein E, and smoking) were used to test the hypothesis that periodontal disease assessed by clinical attachment loss was associated with brain Aβ load using (11)C-Pittsburgh compound B (PIB) positron emission tomography imaging. After adjusting for confounders, clinical attachment loss (≥3 mm), representing a history of periodontal inflammatory/infectious burden, was associated with increased PIB uptake in Aβ vulnerable brain regions (p = 0.002). We show for the first time in humans an association between periodontal disease and brain Aβ load. These data are consistent with the previous animal studies showing that peripheral inflammation/infections are sufficient to produce brain Aβ accumulations. |
DOI | 10.1016/j.neurobiolaging.2014.10.038 |
Alternate Journal | Neurobiol Aging |
PubMed ID | 25491073 |
PubMed Central ID | PMC4399973 |
Grant List | UL1 TR001445 / TR / NCATS NIH HHS / United States R01 AG022374 / AG / NIA NIH HHS / United States R03 DE023139 / DE / NIDCR NIH HHS / United States R01 AG035137 / AG / NIA NIH HHS / United States AG035137 / AG / NIA NIH HHS / United States R21 AG032554 / AG / NIA NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States DE023139-02 / DE / NIDCR NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States AG022374 / AG / NIA NIH HHS / United States AG032554 / AG / NIA NIH HHS / United States AG13616 / AG / NIA NIH HHS / United States 8 UL1 TR000038 / TR / NCATS NIH HHS / United States UL1 TR000038 / TR / NCATS NIH HHS / United States AG12101 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)