Title | Heritability and interindividual variability of regional structure-function coupling. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Gu Z, Jamison KWakefield, Sabuncu MRory, Kuceyeski A |
Journal | Nat Commun |
Volume | 12 |
Issue | 1 |
Pagination | 4894 |
Date Published | 2021 08 12 |
ISSN | 2041-1723 |
Keywords | Adult, Algorithms, Brain, Connectome, Diffusion Magnetic Resonance Imaging, Female, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Nerve Net, Young Adult |
Abstract | White matter structural connections are likely to support flow of functional activation or functional connectivity. While the relationship between structural and functional connectivity profiles, here called SC-FC coupling, has been studied on a whole-brain, global level, few studies have investigated this relationship at a regional scale. Here we quantify regional SC-FC coupling in healthy young adults using diffusion-weighted MRI and resting-state functional MRI data from the Human Connectome Project and study how SC-FC coupling may be heritable and varies between individuals. We show that regional SC-FC coupling strength varies widely across brain regions, but was strongest in highly structurally connected visual and subcortical areas. We also show interindividual regional differences based on age, sex and composite cognitive scores, and that SC-FC coupling was highly heritable within certain networks. These results suggest regional structure-function coupling is an idiosyncratic feature of brain organisation that may be influenced by genetic factors. |
DOI | 10.1038/s41467-021-25184-4 |
Alternate Journal | Nat Commun |
PubMed ID | 34385454 |
PubMed Central ID | PMC8361191 |
Grant List | R21 NS104634 / NS / NINDS NIH HHS / United States R01 LM012719 / LM / NLM NIH HHS / United States R01 AG053949 / AG / NIA NIH HHS / United States RF1 MH123232 / MH / NIMH NIH HHS / United States U54 MH091657 / MH / NIMH NIH HHS / United States R01 NS102646 / NS / NINDS NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)