| Title | F-Positron Emitting/Trimethine Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Kommidi H, Guo H, Nurili F, Vedvyas Y, Jin MM, McClure TD, Ehdaie B, Sayman HB, Akin O, Aras O, Ting R |
| Journal | J Med Chem |
| Volume | 61 |
| Issue | 9 |
| Pagination | 4256-4262 |
| Date Published | 2018 05 10 |
| ISSN | 1520-4804 |
| Keywords | Animals, Carbocyanines, Cell Line, Tumor, Contrast Media, Electrons, Fluorine Radioisotopes, Glutamate Carboxypeptidase II, Male, Mice, Mice, Inbred C57BL, Optical Imaging, Positron-Emission Tomography, Prostatic Neoplasms, Radiochemistry, Tissue Distribution |
| Abstract | [F]-4, an anionic GCPII/PSMA inhibitor for image-guided intervention in prostate cancer, is described. [F]-4 is radiolabeled with a radiochemical yield that is ≥27% and a molar activity of 190 ± 50 mCi/μmol in a <1 h, one-step, aqueous isotopic exchange reaction. [F]-4 allows PSMA expression to be imaged by fluorescence (FL) and [F]-PET. PC3-PIP (PSMA-positive, EC = 6.74 ± 1.33 nM) cancers are specifically delineated in mice that bear 3 million (18 mg) PC3-PIP and PC3 (control, PSMA-negative) cells. Colocalization of [F]-4 PET, fluorescence, scintillated biodistribution, and PSMA expression are observed. |
| DOI | 10.1021/acs.jmedchem.8b00240 |
| Alternate Journal | J Med Chem |
| PubMed ID | 29676909 |
| PubMed Central ID | PMC6263152 |
| Grant List | K99 EB013904 / EB / NIBIB NIH HHS / United States P30 CA008748 / CA / NCI NIH HHS / United States R00 EB013904 / EB / NIBIB NIH HHS / United States R01 CA178007 / CA / NCI NIH HHS / United States |
Related Institute:
Molecular Imaging Innovations Institute (MI3)