| Title | The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: evidence of validity. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Frisoni GB, Jack CR, Bocchetta M, Bauer C, Frederiksen KS, Liu Y, Preboske G, Swihart T, Blair M, Cavedo E, Grothe MJ, Lanfredi M, Martinez O, Nishikawa M, Portegies M, Stoub T, Ward C, Apostolova LG, Ganzola R, Wolf D, Barkhof F, Bartzokis G, DeCarli C, Csernansky JG, deToledo-Morrell L, Geerlings MI, Kaye J, Killiany RJ, Lehéricy S, Matsuda H, O'Brien J, Silbert LC, Scheltens P, Soininen H, Teipel S, Waldemar G, Fellgiebel A, Barnes J, Firbank M, Gerritsen L, Henneman W, Malykhin N, Pruessner JC, Wang L, Watson C, Wolf H, DeLeon M, Pantel J, Ferrari C, Bosco P, Pasqualetti P, Duchesne S, Duvernoy H, Boccardi M |
| Corporate Authors | EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative |
| Journal | Alzheimers Dement |
| Volume | 11 |
| Issue | 2 |
| Pagination | 111-25 |
| Date Published | 2015 Feb |
| ISSN | 1552-5279 |
| Keywords | Aged, Alzheimer Disease, Atrophy, Female, Functional Laterality, Hippocampus, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Internet, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Organ Size, Reproducibility of Results |
| Abstract | BACKGROUND: An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance. METHODS: Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T. RESULTS: The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001). CONCLUSIONS: The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms. |
| DOI | 10.1016/j.jalz.2014.05.1756 |
| Alternate Journal | Alzheimers Dement |
| PubMed ID | 25267715 |
| PubMed Central ID | PMC4422168 |
| Grant List | P41 EB015922 / EB / NIBIB NIH HHS / United States / CAPMC / CIHR / Canada P30 AG013846 / AG / NIA NIH HHS / United States P30 AG008017 / AG / NIA NIH HHS / United States P30AG008017 / AG / NIA NIH HHS / United States P30 AG010129 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)