| Title | Cognitive deficits in non-demented diabetic elderly appear independent of brain amyloidosis. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Chiang GC, Chang E, Pandya S, Kuceyeski A, Hu J, Isaacson R, Ganzer C, Schulman A, Sobel V, Vallabhajosula S, Ravdin L |
| Corporate Authors | Alzheimer's Disease Neuroimaging Initiative |
| Journal | J Neurol Sci |
| Volume | 372 |
| Pagination | 85-91 |
| Date Published | 2017 Jan 15 |
| ISSN | 1878-5883 |
| Keywords | Aged, Amyloidosis, Aniline Compounds, Brain, Case-Control Studies, Cognition Disorders, Diabetes Mellitus, Type 2, Female, Humans, Independent Living, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Positron-Emission Tomography, Thiazoles |
| Abstract | BACKGROUND: To determine the effects of Type 2 diabetes (DM2) on levels of brain amyloidosis and cognition in a community-dwelling cohort of nondemented elderly individuals. METHODS: 33 subjects (16 DM2, 17 nondiabetic) were prospectively recruited. Subjects underwent a PET scan using the amyloid tracer, Pittsburgh Compound B, and a neuropsychological evaluation. Associations between DM2, brain amyloidosis, and cognition were assessed using multivariate regressions, adjusting for age and APOE4 status. RESULTS: DM2 subjects had lower global cognitive function (p=0.018), as measured by the Repeatable Battery for the Assessment of Neuropsychological Status. There was no difference in brain amyloidosis between groups (p=0.25). CONCLUSIONS: Community-dwelling, nondemented individuals with DM2 had greater cognitive deficits, which do not appear to be mediated by brain amyloidosis. Further studies exploring potential mediators of these cognitive deficits should be performed. |
| DOI | 10.1016/j.jns.2016.11.040 |
| Alternate Journal | J Neurol Sci |
| PubMed ID | 28017255 |
| PubMed Central ID | PMC5193167 |
| Grant List | U01 AG024904 / AG / NIA NIH HHS / United States UL1 TR000457 / TR / NCATS NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)