Title | Cluster analysis of time evolution (CAT) for quantitative susceptibility mapping (QSM) and quantitative blood oxygen level-dependent magnitude (qBOLD)-based oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO ) mapping. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Cho J, Zhang S, Kee Y, Spincemaille P, Nguyen TD, Hubertus S, Gupta A, Wang Y |
Journal | Magn Reson Med |
Volume | 83 |
Issue | 3 |
Pagination | 844-857 |
Date Published | 2020 03 |
ISSN | 1522-2594 |
Keywords | Adult, Algorithms, Brain, Brain Mapping, Cerebrovascular Circulation, Cluster Analysis, Computer Simulation, Female, Gray Matter, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Models, Theoretical, Oxygen, Oxygen Consumption, Spin Labels, Stroke, Young Adult |
Abstract | PURPOSE: To improve the accuracy of QSM plus quantitative blood oxygen level-dependent magnitude (QSM + qBOLD or QQ)-based mapping of the oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO ) using cluster analysis of time evolution (CAT). METHODS: 3D multi-echo gradient echo and arterial spin labeling images were acquired in 11 healthy subjects and 5 ischemic stroke patients. DWI was also carried out on patients. CAT was developed for analyzing signal evolution over TE. QQ-based OEF and CMRO were reconstructed with and without CAT, and results were compared using region of interest analysis and a paired t-test. RESULTS: Simulations demonstrated that CAT substantially reduced noise error in QQ-based OEF. In healthy subjects, QQ-based OEF appeared less noisy and more uniform with CAT than without CAT; average OEF with and without CAT in cortical gray matter was 32.7 ± 4.0% and 37.9 ± 4.5%, with corresponding CMRO of 148.4 ± 23.8 and 171.4 ± 22.4 μmol/100 g/min, respectively. In patients, regions of low OEF were confined within the ischemic lesions defined on DWI when using CAT, which was not observed without CAT. CONCLUSION: The cluster analysis of time evolution (CAT) significantly improves the robustness of QQ-based OEF against noise. |
DOI | 10.1002/mrm.27967 |
Alternate Journal | Magn Reson Med |
PubMed ID | 31502723 |
PubMed Central ID | PMC6879790 |
Grant List | S10 OD021782 / OD / NIH HHS / United States R21 EB024366 / EB / NIBIB NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)