News & Events

Alzheimer’s disease (AD) pathology is thought to begin in the brainstem — the brain’s evolutionarily oldest part, which is vital for basic life functions, and, in humans, where tau first accumulates, slowly initiating the AD process. Cerebral microglia, the central nervous system’s most prominent immune cells — the first to respond when the brain goes awry —  play a critical role in AD pathogenesis, yet little is known about brainstem microglia in AD. Translocator protein positron emission tomography (TSPO PET), which is sensitive to activated microglia, shows a high signal...

Congratulations to Moustafa Gabr, Ph.D., Assistant Professor of Chemistry in Radiology, on receiving not one, not two, not three, not even four, but five National Institutes of Health grants, totaling $14.8 million.

"Securing five grants in translational drug discovery highlights my commitment to advancing therapies that bridge laboratory findings to clinical applications," said Dr. Gabr in a recent interview with the Office of the Research Dean. "Each grant targets key challenges...

Alzheimer’s disease (AD), the leading cause of dementia, is on the rise, with U.S. cases estimated to reach 13 million by 2050, according to the Alzheimer’s Association. Despite advances, much remains unknown about AD, namely, why disease severity and progression vary among subjects with similar burdens of Amyloid-beta (Aβ) and tau, two key neuropathological AD markers. This presents challenges for patients, families, clinicians, and researchers. 

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065