Gloria Chiang Laboratory

Associated Lab Members

Gloria Chiang, M.D.
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Gloria ChiangM.D.
  • Associate Professor

Gloria Chiang, M.D., is an associate professor with the Weill Cornell Medicine Department of Radiology Brain Health Imaging Institute (BHII), and with NewYork-Presbyterian Hospital (NYP). She is a board-certified radiologist with subspecialty certification in neuroradiology. Her research program focuses on combining quantitative magnetic resonance and positron emission tomography (MR) and (PET) imaging techniques with plasma and cerebrospinal fluid (CSF) biomarkers to elucidate the pathophysiology of neurodegenerative diseases.  

Lab Achievements

Dr. Gloria Chiang is a Weill Cornell Medicine (WCM) neuroradiologist. Her research program is focused on combining quantitative magnetic resonance and positron emission tomography (QMR) and (PET) imaging techniques with plasma and cerebrospinal fluid (CSF) biomarkers to elucidate neurodegenerative disease pathophysiology. She is currently PI on a National Institutes of Health (NIH) R01 grant. The grant is aimed at investigating longitudinal changes in brain iron and oxidative stress relative to amyloidosis.  Dr. Chiang is Co-I on several other NIH grants, applying innovative imaging techniques to the study of brain aging, multiple sclerosis, and Parkinson’s disease. Previously, she served as Site PI and Co-PI for Alzheimer’s Disease Neuroimaging Initiative (ADNI)-2 and ADNI-Department of Defense (DoD) studies, as well as the Imaging Dementia – Evidence for Amyloid Scanning (IDEAS) Study.  

Currently, she serves on the editorial boards of the American Journal of Neuroradiology (AJNR) and the Journal of Neuroimaging. She is a Senior Member of the American Society of Neuroradiology (ASNR) and serves on the Executive Committee of the American Society of Functional Neuroradiology (ASFNR). She has served on several NIH scientific review panels.  She has been invited to speak on imaging of neurodegenerative diseases at major national and international meetings, including the Radiological Society of North America (RSNA), ASNR, and the American Roentgen Ray Society (ARRS). She has trained over 100 radiology residents and neuroradiology fellows, and has served as a research mentor for more than 20 medical students, graduate students, residents, and fellows. She completed her medical training at Harvard Medical School, followed by a diagnostic radiology residency and neuroradiology fellowship at the University of California, San Francisco, where she was awarded the Margulis Society Outstanding Resident Researcher Award, and an NIH/National Institute of Biomedical Imaging and Bioengineering (NIBIB) Clinician-Scientist Training Grant in Biomedical Imaging. 

Lab Focus

Chiang Laboratory researchers use imaging, cerebrospinal fluid, and plasma biomarkers to investigate the underlying pathophysiology of Alzheimer’s disease (AD) and other neurological disorders.  They are particularly interested in studying modifiable risk factors of these diseases, and using biomarkers to predict cognitive decline at early disease stages, before irreversible neuronal loss has occurred. Recent projects have explored the roles of inflammation and oxidative stress in AD; iron alterations relative to brain amyloidosis; macro- and microstructural-changes in apolipoprotein (APOE) e2 carriers; the relationship between microhemorrhages and tau pathology; and insulin resistance as an AD risk factor.  A key focus of the lab: to identify ways of translating these research techniques and findings into clinical practice, particularly as they pertain to disease heterogeneity, atypical forms of AD, and mixed pathology dementias. 

Collaborators

Tracy Butler, M.D., BHII, WCM
Mony de Leon, Ed.D, BHII, WCM 
Jonathan Dyke, Ph.D., WCM Citigroup Biomedical Imaging Center (CBIC) 
Howard Fine, M.D., WCM Department of Neurology 
Susan Gauthier, D.O., MPH., WCM Department of Neurology 
Makoto Ishii, M.D., Ph.D., WCM Department of Neurology 
John Knisely, M.D., WCM Department of Radiation Oncology 

Ilhami Kovanlikaya, M.D., WCM Department of Radiology  
Yi Li, M.D., Ph.D., WCM Brain health Imaging Institute 
Rajiv Magge, M.D., WCM Department of Neurology 
Anna Nordvig, M.D., WCM Department of Neurology 
Susan Pannullo, M.D., WCM Department of Neurosurgery 

David Pisapia, M.D., WCM Dept of Pathology 
Rohan Ramakrishna, M.D., WCM Deptartment of Neurosurgery 
Lisa Ravdin, Ph.D., WCM Department of Neurology 
Theodore Schwartz, M.D., WCM Department of Neurosurgery 

D
ikoma Shungu, Ph.D., WCM  Laboratory for Advanced MR Spectroscopy Research
 
Yi Wang, Ph.D., MRI Research Institute, WCM

Research Projects

Award or Grant: National Institutes of Health (NIH)/National Institute of Biomedical Imaging and Bioengineering (NIBIB) Clinician-Scientist T32 Training Grant in Biomedical Imaging (2009-2010)

This study used multimodal imaging techniques (voxel-based morphology, arterial spin labeling perfusion, and diffusion...

Award or Grant: R01, National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke (NINDS) (2016-2021)

This study will aim to use brain connectivity to quantitatively model the spread of Parkinson’s disease pathology using a novel “network diffusion” model,...

Award or Grant: R44, National Institutes of Health (NIH)/National Institute of Biomedical Imaging and Bioengineering (NIBIB) (2017-2022)

This study will optimize and validate a k-space weighted image average algorithm for reducing dose of computed tomography (CT)...

Award or Grant: R01, National Institutes of Health (NIH)/National Institute on Aging (NIA) (2020-2025)

Preclinical and postmortem studies have shown that iron colocalizes with beta-amyloid plaques, and iron dyshomeostasis can lead to free radical formation and neuronal loss.  Using...

Award or Grant: National Institutes of Health (NIH)/National Center for Advancing Translational Sciences (NCATS) (2013-2015)

This study investigated the relationships between (1) insulin resistance and brain amyloidosis and, (2) oxidative stress and brain amyloidosis in nondemented...

Award or Grant: Department of Defense (2013-2018)

The Alzheimer’s Disease Neuroimaging Initiative of the Department of Defense (ADNI-DoD) was a multicenter, observational study to determine the effects of traumatic ...

This is a High-End Instrumentation Grant to provide support for a state-of-the-art human whole-body seven Tesla (7T) magnetic resonance imaging (MRI) system as a Special Use Instrument at WCM.

This study will establish the diagnostic accuracy of quantitative susceptibility mapping (QSM) in monitoring disease in multiple sclerosis patients, without the use of intravenous gadolinium, and in predicting acuity of white matter lesions.

This study will establish cellular sources of quantitative susceptibility mapping (QSM) signal in Alzheimer’s disease (AD) brain tissue, and establish QSM as a predictor of neurodegeneration, using structural...

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