Active Research Project
Investigator(s):
Gloria Chiang, M.D.
Related Institute:
Last Updated:
June 7, 2022
Award or Grant: R01, National Institutes of Health (NIH)/National Institute on Aging (NIA) (2020-2025)
Preclinical and postmortem studies have shown that iron colocalizes with beta-amyloid plaques, and iron dyshomeostasis can lead to free radical formation and neuronal loss. Using quantitative susceptibility mapping (QSM), magnetic resonance spectroscopy (MRS), and fluid biomarkers of Alzheimer’s disease (AD), we will investigate longitudinal changes in iron, oxidative stress and neuronal injury related to brain amyloidosis.