The effects of iron on oxidative stress and Alzheimer’s biomarkers in amyloid-positive and negative elderly individuals

Active Research Project
Investigator(s): 
Gloria Chiang, M.D.
Last Updated: 
June 7, 2022

Award or Grant: R01, National Institutes of Health (NIH)/National Institute on Aging (NIA) (2020-2025)

Preclinical and postmortem studies have shown that iron colocalizes with beta-amyloid plaques, and iron dyshomeostasis can lead to free radical formation and neuronal loss.  Using quantitative susceptibility mapping (QSM), magnetic resonance spectroscopy (MRS), and fluid biomarkers of Alzheimer’s disease (AD), we will investigate longitudinal changes in iron, oxidative stress and neuronal injury related to brain amyloidosis.

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065