Quantitative mapping of brain tissue free water in preclinical AD

Active Research Project
Investigator(s): 
Yi Li, M.D., Ph.D.
Last Updated: 
April 8, 2022

This project develops a new biomarker of glymphatic clearance by mapping brain tissue free water. We hypothesize that the increased brain parenchyma cerebrospinal fluid fraction (CSFF) is predictive of ventricular CSF clearance, future amyloid and tau lesions and cognitive decline in Alzheimer's disease. 

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065