New formats of antibodies for imaging and bispecific recognition 

Antibodies are an important class of biologic drugs in oncology and inflammatory disease settings, either in native forms or in modified forms, to carry small molecules or to recognize more than one antigen. Antibodies can also be modified to become molecular diagnosis agents for real-time imaging of diseased cells and tissues in the body. The Jin lab uses in vitro techniques such as phage and yeast display systems, and apply molecular engineering principles to optimize antibodies' affinity, specificity, size and shape for imaging and therapy applications. Specific examples include: