Imaging mass spectrometry to identify key early changes in lipid metabolism of AD mouse models

Active Research Project
Laura Beth McIntire, Ph.D.
Last Updated: 
June 7, 2022

The McIntire lab is studying changes in the brain lipidome using targeted liquid chromatography/mass spectrometry (LC/MS) and untargeted imaging mass spectrometry (IMS) resulting in a system-wide, publically available lipid map. Data from the lab show distinct regional distribution of acyl chain lipid species across mouse brains using desorption electrospray ionization (DESI) mass spectrometry imaging (MSI). 

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065 Phone: (212) 746-6000