Identification of dysregulated lipid pathways for biomarker and therapeutic target discovery

Active Research Project
Laura Beth McIntire, Ph.D.
Last Updated: 
June 16, 2022

To test the hypothesis that manipulation of brain lipid content alters brain lipidome and cognitive function in mouse models of Alzheimer’s disease (AD), we propose to genetically alter the synthetic enzyme, Acyl CoA Synthetase 6 (Acsl6), a key mediator of polyunsaturated fatty acid enrichment in the brain— especially docosahexaenoic acid (DHA) across multiple lipid classes—in mouse models of AD. Lipid content will be determined in the brains of mouse models of AD (APPsw and TRAPOE4) using imaging mass spectrometry for integration of a publicly available lipid brain atlas.

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065