Biomarkers of neurodegeneration in women who have experienced repetitive traumatic brain injury due to intimate partner violence

Active Research Project
Investigator(s): 
Tracy Butler, M.D. Amy Kuceyeski, Ph.D.
Last Updated: 
June 6, 2022

This pilot project will assess positron emission tomography (PET) and magnetic resonance imaging (MRI) biomarkers of neurodegeneration in female victims of intimate partner violence (IPV) with and without TBI.  The goal is to begin to investigate risk Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE) in this highly vulnerable and medically underserved population. While intense research effort has been directed towards understanding risk of CTE in male athletes, especially National Football League (NFL) players, as of 2021, to our knowledge, CTE has been diagnosed in only two women, one of whom was a victim of IPV.  This remarkable, sex-based disparity of research into a disease that is not considered to differ biologically between men and women is unacceptable.  This project is an attempt to help remedy this disparity in accordance with the 2019-2023 Trans-National Institutes of Health (NIH) Strategic Plan for Women’s Health Research. 

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065