Anatomy of the circle of Willis, cerebral blood flow, and Alzheimer's disease biomarkers in hypertension

The Glodzik Lab plans to expand upon their past work describing an optimal blood pressure target, focusing on incomplete variants of the circle of Willis (CoW). The lab's data indicate that incomplete variants play a role in circumstances when there is already a pre-existing impairment of the vascular system. This project will examine whether incomplete variants of the CoW, in the setting of hypertension, necessitate higher perfusion pressure to maintain adequate blood flow, thus increasing the risk for hypoperfusion and Alzheimer’s disease (AD)-related pathology.