Title | TNF-alpha and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Kamer AR, Craig RG, Pirraglia E, Dasanayake AP, Norman RG, Boylan RJ, Nehorayoff A, Glodzik L, Brys M, de Leon MJ |
Journal | J Neuroimmunol |
Volume | 216 |
Issue | 1-2 |
Pagination | 92-7 |
Date Published | 2009 Nov 30 |
ISSN | 1872-8421 |
Keywords | Adult, Aged, Alzheimer Disease, Antibodies, Bacteria, Biomarkers, Causality, Comorbidity, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Periodontitis, Periodontium, Predictive Value of Tests, Tumor Necrosis Factor-alpha, Up-Regulation |
Abstract | The associations of inflammation/immune responses with clinical presentations of Alzheimer's disease (AD) remain unclear. We hypothesized that TNF-alpha and elevated antibodies to periodontal bacteria would be greater in AD compared to normal controls (NL) and their combination would aid clinical diagnosis of AD. Plasma TNF-alpha and antibodies against periodontal bacteria were elevated in AD patients compared with NL and independently associated with AD. The number of positive IgG to periodontal bacteria incremented the TNF-alpha classification of clinical AD and NL. This study shows that TNF-alpha and elevated numbers of antibodies against periodontal bacteria associate with AD and contribute to the AD diagnosis. |
DOI | 10.1016/j.jneuroim.2009.08.013 |
Alternate Journal | J Neuroimmunol |
PubMed ID | 19767111 |
PubMed Central ID | PMC2783848 |
Grant List | M01 RR0096 / RR / NCRR NIH HHS / United States M01 RR000096 / RR / NCRR NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States R01 AG003051 / AG / NIA NIH HHS / United States AG03051 / AG / NIA NIH HHS / United States P30 AG008051-20 / AG / NIA NIH HHS / United States AG08051 / AG / NIA NIH HHS / United States AG12101 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)