Targeted near-IR hybrid magnetic nanoparticles for in vivo cancer therapy and imaging.

TitleTargeted near-IR hybrid magnetic nanoparticles for in vivo cancer therapy and imaging.
Publication TypeJournal Article
Year of Publication2013
AuthorsKirui DK, Khalidov I, Wang Y, Batt CA
JournalNanomedicine
Volume9
Issue5
Pagination702-11
Date Published2013 Jul
ISSN1549-9642
KeywordsAnimals, Cell Line, Tumor, Colorectal Neoplasms, Contrast Media, Diagnostic Imaging, Ferric Compounds, Gold, Humans, Low-Level Light Therapy, Magnetic Resonance Imaging, Magnetite Nanoparticles, Mice, Xenograft Model Antitumor Assays
Abstract

We report the use of immuno-targeted gold-iron oxide hybrid nanoparticles for laser-assisted therapy and for MRI-based imaging as demonstrated in xenograft colorectal cancer tumor model. Immuno-targeted gold-iron oxide nanoparticles selectively accumulate in SW1222 xenograft tumors as compared to the accumulation in non-antigen-expressing tumor xenografts. Effective photothermal treatment using near-IR laser irradiation (808nm, 5W cm(-2)) application is shown where >65% of the antigen-expressing tumor cells presented corrupt extracellular matrix and cytoplasmic acidophilia suggesting effectiveness of nanoparticle-assisted thermal therapy. Cell killing was confirmed by hematoxylin and eosin (H&E) histological staining where scar-like structure containing collagen bundles was observed in the treatment group. Further, systemically injected HNPs were shown to be effective T2 magnetic resonance (MR) imaging contrast agents, localized and detected at the antigen-expressing xenograft tumors. These findings suggest that the new class of bio-conjugated HNPs exhibits great potential for dual-therapy and diagnostics (theranostics) applications.

FROM THE CLINICAL EDITOR: This team reports the successful use of immuno-targeted gold-iron oxide hybrid nanoparticles for both laser-assisted therapy and MRI-based imaging in a xenograft colorectal cancer tumor model, demonstrating strong potentials for dual applications in cancer diagnosis and therapy.

DOI10.1016/j.nano.2012.11.009
Alternate JournalNanomedicine
PubMed ID23219875
Related Institute: 
MRI Research Institute (MRIRI)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065