Spatial patterns of genome-wide expression profiles reflect anatomic and fiber connectivity architecture of healthy human brain.

TitleSpatial patterns of genome-wide expression profiles reflect anatomic and fiber connectivity architecture of healthy human brain.
Publication TypeJournal Article
Year of Publication2014
AuthorsGoel P, Kuceyeski A, LoCastro E, Raj A
JournalHum Brain Mapp
Volume35
Issue8
Pagination4204-18
Date Published2014 Aug
ISSN1097-0193
KeywordsAtlases as Topic, Brain, Brain Mapping, Databases, Genetic, Diffusion Tensor Imaging, Gene Expression, Humans, Magnetic Resonance Imaging, Microarray Analysis, Models, Genetic, Models, Neurological, Neural Pathways
Abstract

Unraveling the relationship between molecular signatures in the brain and their functional, architectonic, and anatomic correlates is an important neuroscientific goal. It is still not well understood whether the diversity demonstrated by histological studies in the human brain is reflected in the spatial patterning of whole brain transcriptional profiles. Using genome-wide maps of transcriptional distribution of the human brain by the Allen Brain Institute, we test the hypothesis that gene expression profiles are specific to anatomically described brain regions. In this work, we demonstrate that this is indeed the case by showing that gene similarity clusters appear to respect conventional basal-cortical and caudal-rostral gradients. To fully investigate the causes of this observed spatial clustering, we test a connectionist hypothesis that states that the spatial patterning of gene expression in the brain is simply reflective of the fiber tract connectivity between brain regions. We find that although gene expression and structural connectivity are not determined by each other, they do influence each other with a high statistical significance. This implies that spatial diversity of gene expressions is a result of mainly location-specific features but is influenced by neuronal connectivity, such that like cellular species preferentially connects with like cells.

DOI10.1002/hbm.22471
Alternate JournalHum Brain Mapp
PubMed ID24677576
PubMed Central IDPMC4283562
Grant ListF32 EB012404-01 / EB / NIBIB NIH HHS / United States
P41 RR023953-S1 / RR / NCRR NIH HHS / United States
P41 RR023953 / RR / NCRR NIH HHS / United States
R01 NS075425 / NS / NINDS NIH HHS / United States
F32 EB012404 / EB / NIBIB NIH HHS / United States
Related Institute: 
Brain Health Imaging Institute (BHII)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065