| Title | Sex specificity of ventral anterior cingulate cortex suppression during a cognitive task. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Butler T, Imperato-McGinley J, Pan H, Voyer D, Cunningham-Bussel AChristine, Chang L, Zhu Y-S, Cordero JJ, Stern E, Silbersweig D |
| Journal | Hum Brain Mapp |
| Volume | 28 |
| Issue | 11 |
| Pagination | 1206-12 |
| Date Published | 2007 Nov |
| ISSN | 1065-9471 |
| Keywords | Adult, Brain Mapping, Cognition, Emotions, Female, Functional Laterality, Gyrus Cinguli, Humans, Imagination, Magnetic Resonance Imaging, Male, Nerve Net, Neural Inhibition, Neuropsychological Tests, Prefrontal Cortex, Psychomotor Performance, Sex Characteristics, Space Perception |
| Abstract | Ventral anterior cingulate cortex (vACC) is a highly interconnected brain region considered to reflect the sometimes competing demands of cognition and emotion. A reciprocal relationship between vACC and dorsal ACC (dACC) may play a role in maintaining this balance between cognitive and emotional processing. Using functional MRI in association with a cognitively-demanding visuospatial task (mental rotation), we found that only women demonstrated vACC suppression and inverse functional connectivity with dACC. Sex differences in vACC functioning--previously described under conditions of negative emotion--are extended here to cognition. Consideration of participant sex is essential to understanding the role of vACC in cognitive and emotional processing. |
| DOI | 10.1002/hbm.20340 |
| Alternate Journal | Hum Brain Mapp |
| PubMed ID | 17315226 |
| PubMed Central ID | PMC6871468 |
| Grant List | M01 RR00047 / RR / NCRR NIH HHS / United States R01 MH0646 / MH / NIMH NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)