| Title | Sensitive luciferin derived probes for selective carboxypeptidase activity. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Chang Y-C, Chao P-W, Tung C-H |
| Journal | Bioorg Med Chem Lett |
| Volume | 21 |
| Issue | 13 |
| Pagination | 3931-4 |
| Date Published | 2011 Jul 01 |
| ISSN | 1464-3405 |
| Keywords | Carboxypeptidases, Luminescent Agents, Molecular Structure, Substrate Specificity |
| Abstract | Highly selective luminescent probes, QLUC-TYR and LUC-GLU, for detection of carboxypeptidase activity were synthesized. Caged substrates were first cleaved by corresponding carboxypeptidases, and then they were activated by luciferase to emit light. Enzymatic activities of biologically important carboxypeptidases can be determined using this technology. |
| DOI | 10.1016/j.bmcl.2011.05.023 |
| Alternate Journal | Bioorg Med Chem Lett |
| PubMed ID | 21640584 |
| PubMed Central ID | PMC3129288 |
| Grant List | R01 CA135312 / CA / NCI NIH HHS / United States R01 CA135312-03 / CA / NCI NIH HHS / United States CA135312 / CA / NCI NIH HHS / United States |
Related Institute:
Molecular Imaging Innovations Institute (MI3)