| Title | Selective photo-ablation of glioma cells using an enzyme activatable photosensitizer. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Shen Z, Tung C-H |
| Journal | Chem Commun (Camb) |
| Volume | 56 |
| Issue | 89 |
| Pagination | 13860-13863 |
| Date Published | 2020 Nov 18 |
| ISSN | 1364-548X |
| Keywords | Animals, Antineoplastic Agents, Cell Line, Tumor, Cell Proliferation, Cell Survival, Drug Screening Assays, Antitumor, Enzyme Activators, gamma-Glutamyltransferase, Glioma, Humans, Methylene Blue, Molecular Structure, Optical Imaging, Photochemotherapy, Photosensitizing Agents, Rats |
| Abstract | An activatable photosensitizer based on methylene blue was developed and validated for its efficacy in the selective killing of γ-glutamyl transpeptidase expressing cells. The O deactivation via bond breakage, rapid in situ enzymatic photosensitivity conversion, long lysosomal retention, and nucleus relocation collectively contribute to its strong and selective photodynamic effects. |
| DOI | 10.1039/d0cc05707j |
| Alternate Journal | Chem Commun (Camb) |
| PubMed ID | 33089272 |
Related Institute:
Molecular Imaging Innovations Institute (MI3)