| Title | A Quick Responsive Fluorogenic pH Probe for Ovarian Tumor Imaging. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Tung C-H, Qi J, Hu L, Han MShin, Kim Y |
| Journal | Theranostics |
| Volume | 5 |
| Issue | 10 |
| Pagination | 1166-74 |
| Date Published | 2015 |
| ISSN | 1838-7640 |
| Keywords | Animals, Cell Line, Tumor, Female, Fluorescence, Humans, Mice, Mice, Inbred BALB C, Mice, Nude, Microscopy, Fluorescence, Molecular Imaging, Molecular Probes, Ovarian Neoplasms |
| Abstract | A novel cell-permeable compound, CypH-1, that is non-fluorescent at neutral pH, but fluoresces under mildly acidic conditions with a near infrared maximum emission wavelength was designed for the detection of tumors in the clinical setting. The potential of CypH-1 in ovarian cancer imaging was demonstrated using a murine model. The intraperitoneally administered CypH-1 results in a robust fluorescence signal of discrete neoplastic lesions with millimeter range resolution within few hours. Moreover, fluorescence signal is strikingly enhanced at peripheral regions of tumors at the microscopic level suggesting a sharp physiological difference at the tumor/normal tissue interface. This robust acid-activated imaging agent is expected to have significant impact in broad surgical and diagnostic applications. |
| DOI | 10.7150/thno.12813 |
| Alternate Journal | Theranostics |
| PubMed ID | 26284146 |
| PubMed Central ID | PMC4533099 |
| Grant List | CA135312 / CA / NCI NIH HHS / United States GM094880 / GM / NIGMS NIH HHS / United States |
Related Institute:
Molecular Imaging Innovations Institute (MI3)