Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's disease.

TitleQuantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's disease.
Publication TypeJournal Article
Year of Publication2007
AuthorsMosconi L, Tsui WH, Rusinek H, de Santi S, Li Y, Wang G-J, Pupi A, Fowler J, de Leon MJ
JournalEur J Nucl Med Mol Imaging
Volume34
Issue9
Pagination1467-79
Date Published2007 Sep
ISSN1619-7070
KeywordsAged, Aged, 80 and over, Alzheimer Disease, Brain, Cognition, Female, Glucose, Hippocampus, Humans, Kinetics, Magnetic Resonance Imaging, Male, Middle Aged, Models, Statistical, Phosphorylation, Positron-Emission Tomography
Abstract

PURPOSE: To examine CMRglc measures and corresponding glucose transport (K1 and k2) and phosphorylation (k3) rates in the medial temporal lobe (MTL, comprising the hippocampus and amygdala) and posterior cingulate cortex (PCC) in mild Alzheimer's disease (AD).

METHODS: Dynamic FDG PET with arterial blood sampling was performed in seven mild AD patients (age 68+/-8 years, four females, median MMSE 23) and six normal (NL) elderly (age 69+/-9 years, three females, median MMSE 30). Absolute CMRglc (micromol/100 g/min) was calculated from MRI-defined regions of interest using multiparametric analysis with individually fitted kinetic rate constants, Gjedde-Patlak plot, and Sokoloff's autoradiographic method with population-based rate constants. Relative ROI/pons CMRglc (unitless) was also examined.

RESULTS: With all methods, AD patients showed significant CMRglc reductions in the hippocampus and PCC, and a trend towards reduced parietotemporal CMRglc, as compared with NL. Significant k3 reductions were found in the hippocampus, PCC and amygdala. K1 reductions were restricted to the hippocampus. Relative CMRglc had the largest effect sizes in separating AD from NL. However, the magnitude of CMRglc reductions was 1.2- to 1.9-fold greater with absolute than with relative measures.

CONCLUSION: CMRglc reductions are most prominent in the MTL and PCC in mild AD, as detected with both absolute and relative CMRglc measures. Results are discussed in terms of clinical and pharmaceutical applicability.

DOI10.1007/s00259-007-0406-5
Alternate JournalEur J Nucl Med Mol Imaging
PubMed ID17406865
Grant ListAG022374 / AG / NIA NIH HHS / United States
AG08051 / AG / NIA NIH HHS / United States
AG12101 / AG / NIA NIH HHS / United States
AG13616 / AG / NIA NIH HHS / United States
M01RR0096 / RR / NCRR NIH HHS / United States
Related Institute: 
Brain Health Imaging Institute (BHII)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065