Title | Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Thuillier P, Bourhis D, Metges JPhilippe, Le Pennec R, Amrane K, Schick U, Blanc-Beguin F, Hennebicq S, Salaun P-Y, Kerlan V, Karakatsanis N, Abgral R |
Journal | Sci Rep |
Volume | 11 |
Issue | 1 |
Pagination | 4727 |
Date Published | 2021 03 01 |
ISSN | 2045-2322 |
Keywords | Adult, Aged, Female, Humans, Male, Middle Aged, Neuroendocrine Tumors, Octreotide, Organometallic Compounds, Positron Emission Tomography Computed Tomography, Radionuclide Imaging, Spleen, Tomography, X-Ray Computed |
Abstract | To present the feasibility of a dynamic whole-body (DWB) Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors (WD-NETs). Sixty-one patients who underwent a DWB Ga-DOTATOC-PET/CT for a histologically proven/highly suspected WD-NET were prospectively included. The acquisition consisted in single-bed dynamic acquisition centered on the heart, followed by the DWB and static acquisitions. For liver, spleen and tumor (1-5/patient), Ki values (in ml/min/100 ml) were calculated according to Patlak's analysis and tumor-to-liver (TLR-Ki) and tumor-to-spleen ratios (TSR-Ki) were recorded. Ki-based parameters were compared to static parameters (SUVmax/SUVmean, TLR/TSRmean, according to liver/spleen SUVmean), in the whole-cohort and according to the PET system (analog/digital). A correlation analysis between SUVmean/Ki was performed using linear and non-linear regressions. Ki-liver was not influenced by the PET system used, unlike SUVmax/SUVmean. The regression analysis showed a non-linear relation between Ki/SUVmean (R = 0.55,0.68 and 0.71 for liver, spleen and tumor uptake, respectively) and a linear relation between TLRmean/TLR-Ki (R = 0.75). These results were not affected by the PET system, on the contrary of the relation between TSRmean/TSR-Ki (R = 0.94 and 0.73 using linear and non-linear regressions in digital and analog systems, respectively). Our study is the first showing the feasibility of a DWB Ga-DOTATOC-PET/CT acquisition in WD-NETs. |
DOI | 10.1038/s41598-021-83965-9 |
Alternate Journal | Sci Rep |
PubMed ID | 33649421 |
PubMed Central ID | PMC7921579 |