Title | Pre-Diabetes, but not Type 2 Diabetes, Is Related to Brain Amyloid in Late Middle-Age. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Luchsinger JA, Palta P, Rippon B, Sherwood G, Soto L, Ceballos F, Laing K, Igwe K, He H, Razlighi Q, Teresi J, Moreno H, Brickman AM |
Journal | J Alzheimers Dis |
Volume | 75 |
Issue | 4 |
Pagination | 1241-1252 |
Date Published | 2020 |
ISSN | 1875-8908 |
Keywords | Aged, Amyloid beta-Peptides, Brain, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Glucose Tolerance Test, Hispanic or Latino, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography, Prediabetic State |
Abstract | BACKGROUND: Type 2 diabetes is a dementia risk factor, but its relation to Alzheimer's disease (AD), the most common cause of dementia, is unclear. OBJECTIVE: Our primary objective was to examine the association of pre-diabetes and type 2 diabetes with brain amyloid-β (Aβ), the putative main culprit of AD. Our secondary objective was to examine the association of pre-diabetes and type 2 diabetes with neurodegeneration, cerebrovascular disease (CVD), and memory performance. METHODS: We conducted a cross-sectional study of 350 late middle-aged Hispanics without dementia in New York City. We classified diabetes status as normal glucose tolerance (NGT), pre-diabetes, and type 2 diabetes following American Diabetes Association criteria. Brain Aβ was ascertained as global Aβ standardized value uptake ratio using PET with 18F-Florbetaben. Neurodegeneration was operationalized as cortical thickness in regions affected by AD using MRI. CVD was operationalized as white matter hyperintensity volume (WMH) on MRI, and memory as performance with the selective reminding test (SRT). RESULTS: Mean age was 64.15±3.34 years, 72.00% were women, and 35.43% were APOEɛ4 carriers. Pre-diabetes, but not type 2 diabetes, was associated with higher Aβ compared with NGT. Type 2 diabetes treatment was related to lower Aβ. Type 2 diabetes was related to lower cortical thickness, higher WMH, and lower SRT score. CONCLUSION: Pre-diabetes, but not type 2 diabetes, is associated with higher brain Aβ in late middle age, and this observation could be explained by the relation of diabetes treatment with lower brain Aβ. Whether type 2 diabetes treatment lowers brain Aβ requires further study. |
DOI | 10.3233/JAD-200232 |
Alternate Journal | J Alzheimers Dis |
PubMed ID | 32390636 |
PubMed Central ID | PMC7659021 |
Grant List | R01 AG050440 / AG / NIA NIH HHS / United States K24 AG045334 / AG / NIA NIH HHS / United States P30 AG059303 / AG / NIA NIH HHS / United States RF1 AG051556 / AG / NIA NIH HHS / United States UL1 TR001873 / TR / NCATS NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)