Title | The Potential of High Resolution Magnetic Resonance Microscopy in the Pathologic Analysis of Resected Breast and Lymph Tissue. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Dashevsky BZ, D'Alfonso T, Sutton EJ, Giambrone A, Aronowitz E, Morris EA, Juluru K, Ballon DJ |
Journal | Sci Rep |
Volume | 5 |
Pagination | 17435 |
Date Published | 2015 Dec 07 |
ISSN | 2045-2322 |
Keywords | Breast, Diagnostic Imaging, Female, Humans, Lymph Nodes, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Microscopy, Surveys and Questionnaires |
Abstract | Pathologic evaluation of breast specimens requires a fixation and staining procedure of at least 12 hours duration, delaying diagnosis and post-operative planning. Here we introduce an MRI technique with a custom-designed radiofrequency resonator for imaging breast and lymph tissue with sufficient spatial resolution and speed to guide pathologic interpretation and offer value in clinical decision making. In this study, we demonstrate the ability to image breast and lymphatic tissue using 7.0 Tesla MRI, achieving a spatial resolution of 59 × 59 × 94 μm(3) with a signal-to-noise ratio of 15-20, in an imaging time of 56 to 70 minutes. These are the first MR images to reveal characteristic pathologic features of both benign and malignant breast and lymph tissue, some of which were discernible by blinded pathologists who had no prior training in high resolution MRI interpretation. |
DOI | 10.1038/srep17435 |
Alternate Journal | Sci Rep |
PubMed ID | 26639673 |
PubMed Central ID | PMC4671009 |
Related Institute:
MRI Research Institute (MRIRI)