Title | Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Glodzik L, de Santi S, Tsui WHon, Mosconi L, Zinkowski R, Pirraglia E, Wang HYu, Li Y, Rich KE, Zetterberg H, Blennow K, Mehta P, de Leon MJ |
Journal | Neurobiol Aging |
Volume | 32 |
Issue | 12 |
Pagination | 2131-41 |
Date Published | 2011 Dec |
ISSN | 1558-1497 |
Keywords | Aged, Aged, 80 and over, Atrophy, Biomarkers, Cognition Disorders, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Memory Disorders, Middle Aged, Phosphorylation, tau Proteins, Temporal Lobe |
Abstract | Little is known whether cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) can predict both memory decline and associated longitudinal medial temporal lobe (MTL) gray matter (GM) reductions in cognitively healthy individuals. Fifty-seven normal elderly subjects received comprehensive evaluation at baseline and 2 years later. The baseline phosphorylated tau(231) (p-tau(231)), total tau, the amyloid beta (Aβ) Aβ42/Aβ40, t-tau/Aβ42 and p-tau(231)/Aβ42 ratios were examined as predictors of memory change and reductions in the global and MTL GM, determined from T1-weighted MRI. Twenty out of 57 participants experienced reduced memory performance at follow-up. The group with decreased memory performance showed higher baseline p-tau(231) (Z=-2.2, p=0.03), lower Aβ42/Aβ40 (t=-2.2 [55], p=0.04) and greater longitudinal MTL GM reductions (t([52])=-2.70, p=0.01). Higher baseline p-tau(231) was also associated with the absolute decrease in memory scores (rho=-0.30, p=0.02) and with longitudinal MTL GM reduction (F([2,52])=4.4, p=0.04, age corrected). Our results indicate that in normal individuals, elevated p-tau(231), a marker of neurofibrillary pathology is related to both a decrease in declarative memory and progressive atrophy of the MTL, suggesting its diagnostic potential in preclinical stage. |
DOI | 10.1016/j.neurobiolaging.2009.12.026 |
Alternate Journal | Neurobiol Aging |
PubMed ID | 20133017 |
PubMed Central ID | PMC3179835 |
Grant List | R01 AG022374 / AG / NIA NIH HHS / United States P30 AG008051-129005 / AG / NIA NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States AG08051 / AG / NIA NIH HHS / United States R01 AG022374-05 / AG / NIA NIH HHS / United States AG12101 / AG / NIA NIH HHS / United States AG022374 / AG / NIA NIH HHS / United States R01 AG012101-15S1 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)