Title | Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Kamer AR, Fortea JO, Videla S, Mayoral A, Janal M, Carmona-Iragui M, Benejam B, Craig RG, Saxena D, Corby P, Glodzik L, Annam KRaghava Ch, Robbins M, de Leon MJ |
Journal | Alzheimers Dement (Amst) |
Volume | 2 |
Pagination | 49-57 |
Date Published | 2016 |
ISSN | 2352-8729 |
Abstract | People with Down syndrome (DS) are at an increased risk for Alzheimer's disease (AD). After 60 years of age, >50% of DS subjects acquire dementia. Nevertheless, the age of onset is highly variable possibly because of both genetic and environmental factors. Genetics cannot be modified, but environmental risk factors present a potentially relevant intervention for DS persons at risk for AD. Among them, inflammation, important in AD of DS type, is potential target. Consistent with this hypothesis, chronic peripheral inflammation and infections may contribute to AD pathogenesis in DS. People with DS have an aggressive form of periodontitis characterized by rapid progression, significant bacterial and inflammatory burden, and an onset as early as 6 years of age. This review offers a hypothetical mechanistic link between periodontitis and AD in the DS population. Because periodontitis is a treatable condition, it may be a readily modifiable risk factor for AD. |
DOI | 10.1016/j.dadm.2016.01.001 |
Alternate Journal | Alzheimers Dement (Amst) |
PubMed ID | 27239536 |
PubMed Central ID | PMC4879643 |
Grant List | UL1 TR001445 / TR / NCATS NIH HHS / United States R01 AG022374 / AG / NIA NIH HHS / United States R03 DE023139 / DE / NIDCR NIH HHS / United States R01 AG035137 / AG / NIA NIH HHS / United States R21 AG032554 / AG / NIA NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States UL1 TR000038 / TR / NCATS NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)