Title | Peptide-based biomaterials for protease-enhanced drug delivery. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Law B, Weissleder R, Tung C-H |
Journal | Biomacromolecules |
Volume | 7 |
Issue | 4 |
Pagination | 1261-5 |
Date Published | 2006 Apr |
ISSN | 1525-7797 |
Keywords | Biocompatible Materials, Drug Delivery Systems, Gels, Peptide Hydrolases, Peptides, Solutions, Time Factors, Water |
Abstract | Controlled delivery of drugs in response to environments has the potential of targeting therapies and personalized treatments. Here, we described self-assembled peptide sequences that release therapeutic payloads upon specific interaction with disease-associated proteases. The core peptide sequence consists of a protease cleavable region flanked by two self-assembly motifs. In aqueous solution, the peptides self-assemble as a gel scaffold. With treatment of the model preparations with the appropriate protease, the matrix can be degraded in a controlled fashion, where the degradation rate is fine-tuned by varying the peptide compositions. Protease-mediated drug release was demonstrated by enzymatic treatment of a model therapeutic peptide incorporated into the optimized matrix. Our results suggest that this type of material may have far-reaching applications for functionally targeted drug delivery. |
DOI | 10.1021/bm050920f |
Alternate Journal | Biomacromolecules |
PubMed ID | 16602747 |
Grant List | P50-CA86355 / CA / NCI NIH HHS / United States R01 CA99385 / CA / NCI NIH HHS / United States |
Related Institute:
Molecular Imaging Innovations Institute (MI3)