Peptide-based biomaterials for protease-enhanced drug delivery.

TitlePeptide-based biomaterials for protease-enhanced drug delivery.
Publication TypeJournal Article
Year of Publication2006
AuthorsLaw B, Weissleder R, Tung C-H
JournalBiomacromolecules
Volume7
Issue4
Pagination1261-5
Date Published2006 Apr
ISSN1525-7797
KeywordsBiocompatible Materials, Drug Delivery Systems, Gels, Peptide Hydrolases, Peptides, Solutions, Time Factors, Water
Abstract

Controlled delivery of drugs in response to environments has the potential of targeting therapies and personalized treatments. Here, we described self-assembled peptide sequences that release therapeutic payloads upon specific interaction with disease-associated proteases. The core peptide sequence consists of a protease cleavable region flanked by two self-assembly motifs. In aqueous solution, the peptides self-assemble as a gel scaffold. With treatment of the model preparations with the appropriate protease, the matrix can be degraded in a controlled fashion, where the degradation rate is fine-tuned by varying the peptide compositions. Protease-mediated drug release was demonstrated by enzymatic treatment of a model therapeutic peptide incorporated into the optimized matrix. Our results suggest that this type of material may have far-reaching applications for functionally targeted drug delivery.

DOI10.1021/bm050920f
Alternate JournalBiomacromolecules
PubMed ID16602747
Grant ListP50-CA86355 / CA / NCI NIH HHS / United States
R01 CA99385 / CA / NCI NIH HHS / United States
Related Institute: 
Molecular Imaging Innovations Institute (MI3)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065