Title | A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Sacktor N, Skolasky RL, Ernst T, Mao X, Selnes O, Pomper MG, Chang L, Zhong K, Shungu DC, Marder K, Shibata D, Schifitto G, Bobo L, Barker PB |
Journal | J Magn Reson Imaging |
Volume | 21 |
Issue | 4 |
Pagination | 325-33 |
Date Published | 2005 Apr |
ISSN | 1053-1807 |
Keywords | Adult, AIDS Dementia Complex, Brain Chemistry, Creatinine, Female, Humans, Inositol, Magnetic Resonance Spectroscopy, Male |
Abstract | PURPOSE: To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia. MATERIALS AND METHODS: Twenty HIV-positive (HIV+) individuals underwent SV-MRS (TE 35 msec) and MRSI (TE 280 msec). Results were stratified according to serostatus, dementia severity, psychomotor speed performance, and functional impairment. RESULTS: HIV+ individuals with psychomotor slowing had an increased myoinositol/creatine (mI/Cr) ratio (0.63 vs. 0.45) in the frontal white matter using SV-MRS and an increased choline (Cho)/Cr ratio (1.88 vs. 1.41) in the mesial frontal gray matter using MRSI compared to HIV+ individuals without psychomotor slowing. Using MRSI, subjects with HIV dementia also had a decreased N-acetyl aspartate (NAA)/Cho ratio (1.55 vs. 2.53) compared to HIV+ individuals without cognitive impairment in the mesial frontal gray matter. Both techniques detected metabolite ratio abnormalities associated with abnormal functional performance. CONCLUSION: SV-MRS and MRSI offer complementary roles in evaluating individuals with HIV dementia. Short TE SV-MRS measures mI, which may be elevated in early HIV dementia, whereas MRSI provides wider spatial coverage to examine specific regional changes. |
DOI | 10.1002/jmri.20272 |
Alternate Journal | J Magn Reson Imaging |
PubMed ID | 15779034 |
Grant List | MH61438 / MH / NIMH NIH HHS / United States NS26643 / NS / NINDS NIH HHS / United States NS32228 / NS / NINDS NIH HHS / United States RR00522 / RR / NCRR NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)