Title | Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Mosconi L, Tsui WH, Herholz K, Pupi A, Drzezga A, Lucignani G, Reiman EM, Holthoff V, Kalbe E, Sorbi S, Diehl-Schmid J, Perneczky R, Clerici F, Caselli R, Beuthien-Baumann B, Kurz A, Minoshima S, de Leon MJ |
Journal | J Nucl Med |
Volume | 49 |
Issue | 3 |
Pagination | 390-8 |
Date Published | 2008 Mar |
ISSN | 0161-5505 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Cognition Disorders, Dementia, Europe, Female, Fluorodeoxyglucose F18, Humans, Male, Middle Aged, Positron-Emission Tomography, Prevalence, Radiopharmaceuticals, Reference Standards, Reproducibility of Results, Sensitivity and Specificity, United States |
Abstract | UNLABELLED: This multicenter study examined (18)F-FDG PET measures in the differential diagnosis of Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB) from normal aging and from each other and the relation of disease-specific patterns to mild cognitive impairment (MCI). METHODS: We examined the (18)F-FDG PET scans of 548 subjects, including 110 healthy elderly individuals ("normals" or NLs), 114 MCI, 199 AD, 98 FTD, and 27 DLB patients, collected at 7 participating centers. Individual PET scans were Z scored using automated voxel-based comparison with generation of disease-specific patterns of cortical and hippocampal (18)F-FDG uptake that were then applied to characterize MCI. RESULTS: Standardized disease-specific PET patterns were developed that correctly classified 95% AD, 92% DLB, 94% FTD, and 94% NL. MCI patients showed primarily posterior cingulate cortex and hippocampal hypometabolism (81%), whereas neocortical abnormalities varied according to neuropsychological profiles. An AD PET pattern was observed in 79% MCI with deficits in multiple cognitive domains and 31% amnesic MCI. (18)F-FDG PET heterogeneity in MCI with nonmemory deficits ranged from absent hypometabolism to FTD and DLB PET patterns. CONCLUSION: Standardized automated analysis of (18)F-FDG PET scans may provide an objective and sensitive support to the clinical diagnosis in early dementia. |
DOI | 10.2967/jnumed.107.045385 |
Alternate Journal | J Nucl Med |
PubMed ID | 18287270 |
PubMed Central ID | PMC3703818 |
Grant List | R01 AG022374 / AG / NIA NIH HHS / United States M01 RR000096 / RR / NCRR NIH HHS / United States R01 AG013616 / AG / NIA NIH HHS / United States R01 AG012101 / AG / NIA NIH HHS / United States AG022374 / AG / NIA NIH HHS / United States AG13616 / AG / NIA NIH HHS / United States M01RR0096 / RR / NCRR NIH HHS / United States AG08051 / AG / NIA NIH HHS / United States AG12101 / AG / NIA NIH HHS / United States U01 AG016976 / AG / NIA NIH HHS / United States P30 AG008051 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)