Title | Multicenter reproducibility of quantitative susceptibility mapping in a gadolinium phantom using MEDI+0 automatic zero referencing. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Deh K, Kawaji K, Bulk M, Van Der Weerd L, Lind E, Spincemaille P, Gillen KMcCabe, Van Auderkerke J, Wang Y, Nguyen TD |
Journal | Magn Reson Med |
Volume | 81 |
Issue | 2 |
Pagination | 1229-1236 |
Date Published | 2019 02 |
ISSN | 1522-2594 |
Keywords | Algorithms, Artifacts, Brain, Brain Mapping, Gadolinium, Humans, Image Interpretation, Computer-Assisted, Image Processing, Computer-Assisted, Iron, Magnetic Resonance Imaging, Pattern Recognition, Automated, Phantoms, Imaging, Regression Analysis, Reproducibility of Results, Signal-To-Noise Ratio |
Abstract | PURPOSE: To determine the reproducibility of quantitative susceptibility mapping at multiple sites on clinical and preclinical scanners (1.5 T, 3 T, 7 T, and 9.4 T) from different vendors (Siemens, GE, Philips, and Bruker) for standardization of multicenter studies. METHODS: Seven phantoms distributed from the core site, each containing 5 compartments with gadolinium solutions with fixed concentrations between 0.625 mM and 10 mM. Multi-echo gradient echo scans were performed at 1.5 T, 3 T, 7 T, and 9.4 T on 12 clinical and 3 preclinical scanners. DICOM images from the scans were processed into quantitative susceptibility maps using the Laplacian boundary value (LBV) and MEDI+0 automatic uniform reference algorithm. Region of interest (ROI) analyses were performed by a physicist to determine agreement between results from all sites. Measurement reproducibility was assessed using regression, Bland-Altman plots, and the intra-class correlation coefficient (ICC). RESULTS: Quantitative susceptibility mapping (QSM) from all scanners had similar, artifact-free visual appearance. Regression analysis showed a linear relationship between gadolinium concentrations and average QSM measurements for all phantoms (y = 350x - 0.0346, r >0.99). The SD of measurements increased almost linearly from 32 ppb to 230 ppb as the measured susceptibility increased from 0.26 ppm to 3.56 ppm. A Bland-Altman plot showed the bias, upper, and lower limits of agreement for all comparisons were -10, -210, and 200 ppb, respectively. The ICC was 0.991 with a 95% CI (0.973, 0.99). CONCLUSIONS: QSM shows excellent multicenter reproducibility for a large range of susceptibility values encountered in cranial and extra-cranial applications on a diverse set of scanner platforms. |
DOI | 10.1002/mrm.27410 |
Alternate Journal | Magn Reson Med |
PubMed ID | 30284727 |
PubMed Central ID | PMC6289704 |
Grant List | R21 EB024366 / EB / NIBIB NIH HHS / United States R21 EY027568 / EY / NEI NIH HHS / United States 5F31EB019883-02 / EB / NIBIB NIH HHS / United States R01 NS090464 / NS / NINDS NIH HHS / United States R01 NS095562 / NS / NINDS NIH HHS / United States S10 OD021782 / OD / NIH HHS / United States R01 CA181566 / CA / NCI NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)