Title | Microglial activation, but not tau pathology, is independently associated with amyloid positivity and memory impairment. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Zou J, Tao S, Johnson A, Tomljanovic Z, Polly K, Klein J, Razlighi QR, Brickman AM, Lee S, Stern Y, Kreisl WCharles |
Journal | Neurobiol Aging |
Volume | 85 |
Pagination | 11-21 |
Date Published | 2020 01 |
ISSN | 1558-1497 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Female, Humans, Male, Memory Disorders, Microglia, Middle Aged, Positron-Emission Tomography, tau Proteins |
Abstract | We sought to determine if upstream amyloid accumulation and downstream cognitive impairment have independent relationships with microglial activation and tau pathology. Fifty-eight older adults were stratified by amyloid and cognitive status based on F-florbetaben PET, history, and neuropsychological testing. Of these, 57 had C-PBR28 PET to measure microglial activation and 43 had F-MK-6240 PET to measure tau pathology. Amyloid and cognitive status were associated with increased overall binding for both C-PBR28 and F-MK-6240 (p's < 0.01). While there was no interaction between amyloid and cognitive status in their association with C-PBR28 binding (p = 0.6722), there was an interaction in their association with F-MK-6240 binding (p = 0.0115). Binding of both radioligands was greater in amyloid-positive controls than in amyloid-negative controls; however, this difference was seen in neocortical regions for C-PBR28 and only in medial temporal cortex for F-MK-6240. We conclude that, in the absence of cognitive symptoms, amyloid deposition has a greater association with microglial activation than with tau pathology. |
DOI | 10.1016/j.neurobiolaging.2019.09.019 |
Alternate Journal | Neurobiol Aging |
PubMed ID | 31698286 |
PubMed Central ID | PMC6919274 |
Grant List | R56 AG034189 / AG / NIA NIH HHS / United States P50 AG008702 / AG / NIA NIH HHS / United States RF1 AG054023 / AG / NIA NIH HHS / United States R01 AG037212 / AG / NIA NIH HHS / United States UL1 TR000040 / TR / NCATS NIH HHS / United States RF1 AG038465 / AG / NIA NIH HHS / United States P01 AG007232 / AG / NIA NIH HHS / United States K23 AG052633 / AG / NIA NIH HHS / United States P30 AG066462 / AG / NIA NIH HHS / United States R01 AG026158 / AG / NIA NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)