Title | Measurement of cellular-interstitial water exchange time in tumors based on diffusion-time-dependent diffusional kurtosis imaging. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Zhang J, Lemberskiy G, Moy L, Fieremans E, Novikov DS, Kim SGene |
Journal | NMR Biomed |
Volume | 34 |
Issue | 6 |
Pagination | e4496 |
Date Published | 2021 06 |
ISSN | 1099-1492 |
Keywords | Animals, Brain Neoplasms, Breast Neoplasms, Diffusion Tensor Imaging, Disease Models, Animal, Female, Glioma, Humans, Mammary Neoplasms, Animal, Mice, Inbred BALB C, Mice, Inbred C57BL, Neoplasms, Water |
Abstract | PURPOSE: To assess the feasibility of using diffusion-time-dependent diffusional kurtosis imaging (tDKI) to measure cellular-interstitial water exchange time (τ ) in tumors, both in animals and in humans. METHODS: Preclinical tDKI studies at 7 T were performed with the GL261 glioma model and the 4T1 mammary tumor model injected into the mouse brain. Clinical studies were performed at 3 T with women who had biopsy-proven invasive ductal carcinoma. tDKI measurement was conducted using a diffusion-weighted STEAM pulse sequence with multiple diffusion times (20-800 ms) at a fixed echo time, while keeping the b-values the same (0-3000 s/mm ) by adjusting the diffusion gradient strength. The tDKI data at each diffusion time t were used for a weighted linear least-squares fit method to estimate the diffusion-time-dependent diffusivity, D(t), and diffusional kurtosis, K(t). RESULTS: Both preclinical and clinical studies showed that, when diffusion time t ≥ 200 ms, D(t) did not have a noticeable change while K(t) decreased monotonically with increasing diffusion time in tumors and t ≥ 100 ms for the cortical ribbon of the mouse brain. The estimated τ averaged median and interquartile range (IQR) of GL261 and 4T1 tumors were 93 (IQR = 89) ms and 68 (78) ms, respectively. For the cortical ribbon, the estimated τ averaged median and IQR were 41 (34) ms for C57BL/6 and 30 (17) ms for BALB/c. For invasive ductal carcinoma, the estimated τ median and IQR of the two breast cancers were 70 (94) and 106 (92) ms. CONCLUSION: The results of this proof-of-concept study substantiate the feasibility of using tDKI to measure cellular-interstitial water exchange time without using an exogenous contrast agent. |
DOI | 10.1002/nbm.4496 |
Alternate Journal | NMR Biomed |
PubMed ID | 33634508 |
PubMed Central ID | PMC8170918 |
Grant List | P30 CA016087 / CA / NCI NIH HHS / United States P30 AG066512 / AG / NIA NIH HHS / United States R01 CA219964 / CA / NCI NIH HHS / United States UH3 CA228699 / CA / NCI NIH HHS / United States S10 OD018337 / OD / NIH HHS / United States UG3 CA228699 / CA / NCI NIH HHS / United States R01 CA160620 / CA / NCI NIH HHS / United States P41 EB017183 / EB / NIBIB NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)