Title | Longitudinal increases in structural connectome segregation and functional connectome integration are associated with better recovery after mild TBI. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Kuceyeski AF, Jamison KW, Owen JP, Raj A, Mukherjee P |
Journal | Hum Brain Mapp |
Volume | 40 |
Issue | 15 |
Pagination | 4441-4456 |
Date Published | 2019 10 15 |
ISSN | 1097-0193 |
Keywords | Adult, Attention, Brain Injuries, Traumatic, Case-Control Studies, Cognition Disorders, Connectome, Convalescence, Diffusion Tensor Imaging, Female, Follow-Up Studies, Humans, Learning Disabilities, Magnetic Resonance Imaging, Male, Memory Disorders, Models, Neurological, Nerve Net, Neuropsychological Tests, Wounds, Nonpenetrating, Young Adult |
Abstract | Traumatic brain injury damages white matter pathways that connect brain regions, disrupting transmission of electrochemical signals and causing cognitive and emotional dysfunction. Connectome-level mechanisms for how the brain compensates for injury have not been fully characterized. Here, we collected serial MRI-based structural and functional connectome metrics and neuropsychological scores in 26 mild traumatic brain injury subjects (29.4 ± 8.0 years, 20 males) at 1 and 6 months postinjury. We quantified the relationship between functional and structural connectomes using network diffusion (ND) model propagation time, a measure that can be interpreted as how much of the structural connectome is being utilized for the spread of functional activation, as captured via the functional connectome. Overall cognition showed significant improvement from 1 to 6 months (t = -2.15, p = .04). None of the structural or functional global connectome metrics was significantly different between 1 and 6 months, or when compared to 34 age- and gender-matched controls (28.6 ± 8.8 years, 25 males). We predicted longitudinal changes in overall cognition from changes in global connectome measures using a partial least squares regression model (cross-validated R = .27). We observe that increased ND model propagation time, increased structural connectome segregation, and increased functional connectome integration were related to better cognitive recovery. We interpret these findings as suggesting two connectome-based postinjury recovery mechanisms: one of neuroplasticity that increases functional connectome integration and one of remote white matter degeneration that increases structural connectome segregation. We hypothesize that our inherently multimodal measure of ND model propagation time captures the interplay between these two mechanisms. |
DOI | 10.1002/hbm.24713 |
Alternate Journal | Hum Brain Mapp |
PubMed ID | 31294921 |
PubMed Central ID | PMC6865536 |
Grant List | / / GE Healthcare / International R01NS092802 / NS / NINDS NIH HHS / United States U01 NS086090 / NS / NINDS NIH HHS / United States R01 NS092802 / NS / NINDS NIH HHS / United States R21 NS104634-01 / NS / NINDS NIH HHS / United States R21 NS104634 / NS / NINDS NIH HHS / United States R01 EB022717 / EB / NIBIB NIH HHS / United States R01 NS102646 / NS / NINDS NIH HHS / United States R01 NS102646-01A1 / NS / NINDS NIH HHS / United States R01 NS060776 / NS / NINDS NIH HHS / United States Junior Faculty Fellowship / / Anna-Maria and Stephen Kellen Foundation / International |
Related Institute:
Brain Health Imaging Institute (BHII)