Layer-by-layer construction of an oxygen-generating photo-responsive nanomedicine for enhanced photothermal and photodynamic combination therapy.

TitleLayer-by-layer construction of an oxygen-generating photo-responsive nanomedicine for enhanced photothermal and photodynamic combination therapy.
Publication TypeJournal Article
Year of Publication2019
AuthorsDu B, Zhang W, Tung C-H
JournalChem Commun (Camb)
Volume55
Issue42
Pagination5926-5929
Date Published2019 May 25
ISSN1364-548X
KeywordsCell Line, Tumor, Humans, Lysosomes, Nanomedicine, Oxygen, Photochemotherapy, Photosensitizing Agents
Abstract

A multifunctional photosensitive and photothermal nanomedicine, AMP-Ce6-HA, was prepared by sequentially layering hard and soft functional molecules. AMP-Ce6-HA was efficiently picked up by MDA-MB-231 breast cancer cells, and then released oxygen in lysosomes. The photothermal and oxygen-enhanced photodynamic combination therapy was much more effective than the single one.

DOI10.1039/c9cc01461f
Alternate JournalChem Commun (Camb)
PubMed ID31049497
Related Institute: 
Molecular Imaging Innovations Institute (MI3)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065