| Title | Human fear-related motor neurocircuitry. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Butler T, Pan H, Tuescher O, Engelien A, Goldstein M, Epstein J, Weisholtz D, Root JC, Protopopescu X, Cunningham-Bussel AC, Chang L, Xie X-H, Chen Q, Phelps EA, Ledoux JE, Stern E, Silbersweig DA |
| Journal | Neuroscience |
| Volume | 150 |
| Issue | 1 |
| Pagination | 1-7 |
| Date Published | 2007 Nov 30 |
| ISSN | 0306-4522 |
| Keywords | Adult, Amygdala, Basal Ganglia, Brain Mapping, Fear, Female, Galvanic Skin Response, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motor Cortex, Neural Pathways, Oxygen, Photic Stimulation |
| Abstract | Using functional magnetic resonance imaging and an experimental paradigm of instructed fear, we observed a striking pattern of decreased activity in primary motor cortex with increased activity in dorsal basal ganglia during anticipation of aversive electrodermal stimulation in 42 healthy participants. We interpret this pattern of activity in motor neurocircuitry in response to cognitively-induced fear in relation to evolutionarily-conserved responses to threat that may be relevant to understanding normal and pathological fear in humans. |
| DOI | 10.1016/j.neuroscience.2007.09.048 |
| Alternate Journal | Neuroscience |
| PubMed ID | 17980493 |
| Grant List | P50 MH058911 / MH / NIMH NIH HHS / United States R01 MH061825 / MH / NIMH NIH HHS / United States P50MH058911 / MH / NIMH NIH HHS / United States 5R01MH061825 / MH / NIMH NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)