Human fear-related motor neurocircuitry.

TitleHuman fear-related motor neurocircuitry.
Publication TypeJournal Article
Year of Publication2007
AuthorsButler T, Pan H, Tuescher O, Engelien A, Goldstein M, Epstein J, Weisholtz D, Root JC, Protopopescu X, Cunningham-Bussel AC, Chang L, Xie X-H, Chen Q, Phelps EA, Ledoux JE, Stern E, Silbersweig DA
JournalNeuroscience
Volume150
Issue1
Pagination1-7
Date Published2007 Nov 30
ISSN0306-4522
KeywordsAdult, Amygdala, Basal Ganglia, Brain Mapping, Fear, Female, Galvanic Skin Response, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motor Cortex, Neural Pathways, Oxygen, Photic Stimulation
Abstract

Using functional magnetic resonance imaging and an experimental paradigm of instructed fear, we observed a striking pattern of decreased activity in primary motor cortex with increased activity in dorsal basal ganglia during anticipation of aversive electrodermal stimulation in 42 healthy participants. We interpret this pattern of activity in motor neurocircuitry in response to cognitively-induced fear in relation to evolutionarily-conserved responses to threat that may be relevant to understanding normal and pathological fear in humans.

DOI10.1016/j.neuroscience.2007.09.048
Alternate JournalNeuroscience
PubMed ID17980493
Grant ListP50 MH058911 / MH / NIMH NIH HHS / United States
R01 MH061825 / MH / NIMH NIH HHS / United States
P50MH058911 / MH / NIMH NIH HHS / United States
5R01MH061825 / MH / NIMH NIH HHS / United States
Related Institute: 
Brain Health Imaging Institute (BHII)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065