| Title | Gold nanorod-photosensitizer complex for near-infrared fluorescence imaging and photodynamic/photothermal therapy in vivo. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Jang B, Park J-Y, Tung C-H, Kim I-H, Choi Y |
| Journal | ACS Nano |
| Volume | 5 |
| Issue | 2 |
| Pagination | 1086-94 |
| Date Published | 2011 Feb 22 |
| ISSN | 1936-086X |
| Keywords | Animals, Biological Transport, Carcinoma, Squamous Cell, Cell Line, Tumor, Cell Transformation, Neoplastic, Female, Gold, Infrared Rays, Intracellular Space, Mice, Microscopy, Fluorescence, Nanotubes, Photochemotherapy, Photosensitizing Agents, Singlet Oxygen |
| Abstract | A gold nanorod (GNR)-photosensitizer complex was developed for noninvasive near-infrared fluorescence imaging and cancer therapy. We showed that (a) fluorescence emission and singlet oxygen generation by AlPcS(4) were quenched after complex formation with GNRs; (b) 4-fold greater intracellular uptake and better in vitro phototoxicity were observed in GNR-AlPcS(4)-treated cells than in free AlPcS(4)-treated cells; and (c) after intravenous injection of the GNR-AlPcS(4) complex, tumor sites were clearly identified on near-infrared fluorescence images as early as 1 h after injection. The tumor-to-background ratio increased over time and was 3.7 at 24 h; tumor growth reduced by 79% with photodynamic therapy (PDT) alone and by 95% with dual photothermal therapy (PTT) and PDT. This novel multifunctional nanomedicine may be useful for near-infrared fluorescence imaging and PTT/PDT in various cancers. |
| DOI | 10.1021/nn102722z |
| Alternate Journal | ACS Nano |
| PubMed ID | 21244012 |
Related Institute:
Molecular Imaging Innovations Institute (MI3)