Title | Fear-related activity in subgenual anterior cingulate differs between men and women. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Butler T, Pan H, Epstein J, Protopopescu X, Tuescher O, Goldstein M, Cloitre M, Yang Y, Phelps E, Gorman J, Ledoux J, Stern E, Silbersweig D |
Journal | Neuroreport |
Volume | 16 |
Issue | 11 |
Pagination | 1233-6 |
Date Published | 2005 Aug 01 |
ISSN | 0959-4965 |
Keywords | Adult, Brain Mapping, Carbamide Peroxide, Drug Combinations, Electric Stimulation, Fear, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Peroxides, Sex Characteristics, Skin, Urea |
Abstract | Functional magnetic resonance imaging in association with an instructed fear/anticipatory anxiety paradigm was used to explore sex differences in the human fear response. During anticipation of mild electrodermal stimulation, women, as compared with men, demonstrated increased activity in the subgenual anterior cingulate cortex and functionally related regions of the insula and brainstem. The subgenual anterior cingulate cortex is a region critical for emotional control implicated in the pathogenesis of psychiatric disease. Present findings suggest a contributory neural substrate for the greater susceptibility of women to anxiety and affective disorders, and emphasize the importance of considering participant sex when designing and interpreting functional neuroimaging studies. |
DOI | 10.1097/00001756-200508010-00020 |
Alternate Journal | Neuroreport |
PubMed ID | 16012355 |
Grant List | 5-P50MH58911 / MH / NIMH NIH HHS / United States |
Related Institute:
Brain Health Imaging Institute (BHII)